Notch Signaling in Health and Disease

Dear Colleagues, 

Notch signaling plays a crucial role in various cellular processes, such as proliferation, differentiation, migration, cellular fate, and death, during both normal development and pathological conditions.

Notch signaling controls the induction of keratinocyte growth, promotes the activation of the differentiation program, and is also involved in the regulation of inflammatory responses. Alterations and hyper- or hypo-activation in Notch signaling molecules and in their target genes can induce failure in the regulation of keratinocyte functions, which, in turn, produces skin diseases.

The pathogenetic role of the Notch pathway in skin diseases is not currently fully understood. In recent years, attention has been focused on the correlation between Notch signaling and skin diseases; Notch signaling alterations have recently been reported for the following five human skin diseases, suggesting the involvement of Notch in their pathogenesis: hidradenitis suppurativa, Dowling-Degos disease, Adams–Oliver syndrome, psoriasis, and atopic dermatitis.

This Special Issue is dedicated to the role of Notch signaling in health and skin diseases. Areas of particular interest include but are not limited to defects in keratinocytes and skin health and diseases, autoinflammatory keratinization diseases, and Notch signaling regulation in health and skin diseases.

Dr. Paola Maura Ticarico
Prof. Dr. Sergio Crovella
Guest Editors

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