Role of NF-κB in Carcinogenesis and Its Therapeutic Regulation
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (31 May 2023) | Viewed by 11078
Special Issue Editor
Interests: cancer; inflammation; transcription factors; vitamin; apoptosis
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The master transcription factor nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) plays an important role in both physiological and pathological conditions. It is an important component of the immune system, but once deregulated, it can promote tumorigenesis by altering the expression of various oncogenic genes. A number of strategies can be employed to target aberrant NF-κB activation, but efforts are still ongoing to identify specific NF-κB blockers that can be effective against various malignancies, especially in clinical studies. This issue will highlight the diverse mechanisms of NF-κB activation in tumor cells, its potential role in oncogenesis and novel approaches to targeting this transcription factor for cancer therapy.
Dr. Gautam Sethi
Guest Editor
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Keywords
- NF-κB
- tumorigenesis
- metastasis
- chemoresistance
- pharmacological inhibition
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