Purinergic Signaling in Neuroinflammation 2.0

Dear Colleagues,

It is clear today that the physiological effect of extracellular ATP is mediated by its interaction with specific purinergic receptors. All purinergic receptors are divided into P1-purinoreceptors (the main ligand is adenosine) and P2-purinoreceptors (the main ligands are ATP/ADP and UTP/UDP). Each of the subtypes is divided into a number of families. For instance, P2 receptors are divided into P2X and P2Y receptors according to the mechanism by which their effect is realized: P2Ys are G-protein coupled receptors, while P2X receptors are ligand-operated ion channels (or ionotropic receptors). P2X receptors are important molecular therapeutic targets, and their malfunctioning results in serious complications in the physiology of humans and animals and can cause dangerous diseases. The search for compounds that can modulate the function of purinergic receptors can result in the creation of new drugs that are effective in the treatment of diseases of the central and peripheral nervous system and immune system, including neuroinflammation, hypoxia/ischemia, epilepsy and neuropathic pain. In this Special Issue, we wish to offer a platform for high-quality publications on the latest advances on the identification of P2X/Y and P1 (A1, A2A, A2B and A3) receptor blockers, their functions and their regulation; the characterization of these receptor signaling networks and crosstalk; mechanisms underlying the role of purinoceptors in neurodegenerative illnesses as well as chronic neuronal changes following acute noxious damage; and therapeutic opportunities associated with the regulation of purinergic receptor activity. This Special Issue will be of interest to researchers working on cell signaling, neurology and immunology and also to chemical biologists interested in drug discovery, as well as clinicians.

Prof. Dr. Peter Illes
Dr. Dmitry Aminin
Guest Editors

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