Proteomics Analysis in Biomarker Discovery

Dear colleagues,

Early and accurate diagnosis is pivotal to achieving successful treatment of complex and often fatal diseases such as cancer and autoimmune, cardiovascular, and neurodegenerative diseases. In clinical practice, the prediction outcomes, and responses to treatment, is also considered of great importance. For a long time, some blood biomarkers have been used as tools for diagnosis and follow-up purposes. Nevertheless, currently available biomarkers, which are far from being comprehensive, often lack specificity, and thus in the last decade omics-based technologies have been extensively used for biomarker discovery. Proteomics analysis of various body fluids such as plasma, serum, and saliva, and tissue specimens, has largely contributed to the detection of new potential biomarkers for various diseases. The constant advance of mass spectrometry techniques has been essential to this ongoing process. In recent years, proteomics analysis of cell culture secretome, cell, and body fluid exomes has also been implemented, leading to new discoveries that have shed light on cell communications in pathological conditions such as cancer. Particularly, exosome protein cargos appear to reflect the pathological state of the originated cells and thus can represent enriched sources of pivotal biomarkers.

Scientists working in the field of proteomics analysis applied to biomarkers discovery for human diseases are encouraged to consider this Special Issue for submitting recent research and review articles. While research dealing with innovative approaches is particularly welcome, proteomics investigations that highlight the molecular mechanisms of diseases are also of interest.

Dr. Maria Rosa Mazzoni
Dr. Laura Giusti
Guest Editors

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