Photodynamic Therapy: Outlook and Future Direction
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (15 October 2023) | Viewed by 9446
Special Issue Editor
2. Department of Orthopedic Dentistry, Faculty of Dentistry, First Moscow State Medical University (Sechenov University), 119991 Moscow, Russia
Interests: cell biology; photobiomodulation; tissue regeneration; bioelectromagnetism; protistology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
In the last 30 years, photodynamic therapy has deservedly achieved a fundamental role of recognition as a medical therapy, above all for its cytotoxic effect, thus allowing professionals to exploit a minimally invasive method capable of being very effective in various fields of medicine.
Photodynamic therapy (PDT) is a method of treating tumours, in particular cancer, the essence of which is the electoral impact on biological tissues as a result of photochemical reactions. Light energy is the catalyst of these reactions.
Photodynamic therapy (PDT) was the first drug–device combination approved by the US Food and Drug Administration (FDA) almost two decades ago, but even so, remains underutilized clinically.
PDT consists of three essential components: a photosensitizer, light, and oxygen. It is obvious that no one of these is individually toxic, but together, they initiate a photochemical reaction that culminates in the generation of a highly reactive product termed singlet oxygen and many free radicals.
Even aPDT (antimicrobial photodynamic therapy) is increasingly considered in cases of treatment of acute or chronic infections thanks to its great ability to create antimicrobial oxidative stress and consequently significantly lower the massive consumption of antibiotic molecules that cause well-known resistance by microorganisms, making treatments for this type of pathology more and more difficult.
However, both therapies are not as widely recognized as they deserve. The hope is that new research, the new combination of photosensitizers and light, and discoveries will make the knowledge of the benefits obtainable from this therapy and can also have these approaches taken into serious consideration by more professionals.
To support this Special Issue, reviews, original articles, and commentaries providing innovative interpretation and results in the field of photodynamic therapy are welcome. Authors are invited to submit manuscripts exploring aspects that point out original molecular pathways and reliable therapies. Novel approaches and state-of-the-art molecules are highly appreciated. Our Special Issue would aim to prove the molecular interactions and the contribution of PDT in therapeutic and diagnostic tools, highlighting their diverse potential and fully developing them for the future.
Dr. Andrea Amaroli
Guest Editor
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Keywords
- photodynamic therapy (PDT)
- photochemical reactions
- photosensitizer
- light
- oxygen
- therapeutic and diagnostic tools
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