Molecular Mechanism of Ovarian Cancer Initiation and Progression
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (25 October 2023) | Viewed by 7128
Special Issue Editor
Special Issue Information
Dear Colleagues,
Ovarian cancer continues to have the highest case-fatality ratio of any gynecologic cancer and is the leading cause of reproductive cancer mortality among women globally. High-grade serous ovarian cancer (HGSOC), the most common histologic subtype, represents 80% of ovarian cancer cases and accounts for the majority of deaths. Although the understanding of ovarian cancer etiology and pathobiology has made recent advances, the overall survival of patients diagnosed with ovarian cancer is still very poor when compared to other gynecological cancers. Factors contributing to poor survival include lack of screening testing, molecular mechanisms of initiation and progression, early peritoneal spread/metastasis, eventual recurrence, and ultimately chemoresistance. Further complicating efforts in early detection is the lack of definitive biomarkers and the role of molecular expression patterns in the initiation and progression of ovarian cancer. Understanding the role of these processes is a crucial step in improving our ability to detect disease at its earliest stages, aiding in the development of testing that can reliably detect disease in its early stages, novel biomarkers, and targeted therapeutic approaches for patients with this disease. This special issue focuses on distinct areas of research across the field of ovarian cancer to identify early molecular events related to initiation and progression. Ultimately, early detection is likely to improve treatment effectiveness and increase the chance of cure, thus decreasing the high rates of mortality associated with ovarian cancer.
Dr. Karuppaiyah Selvendiran
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- early molecular events
- ovarian carcinogenesis
- initiation and progression
- fallopian tube
- HGSOC, genetic mutation
- early detection
- BRCA1/BRCA2
- targeting of OC progression
- animal model for OC initiation
- microarray in OC
- genetic/molecular disorders
- angiogenesis
- cell cycle progression in OC
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue policies can be found here.
