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Molecular Functions of Polyphenols in Health and Diseases
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Molecular Functions of Polyphenols in Health and Diseases

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: closed (20 April 2025) | Viewed by 4581

Special Issue Editor

Dr. Helmut Martin Hügel

E-Mail Website
Guest Editor
School of Science, STEM College, RMIT University, 124 La Trobe Street, Melbourne, VIC 3001, Australia
Interests: medicinal chemistry phytochemical; natural and synthetic molecules; mechanisms to defeat dementia; Alzheimer’s disease; brain-gut axis; dietary directions against dementia; lifestyle modifications
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Obesity, cardiovascular diseases, diabetes, cancer, and dementia are major public health problems. Therefore, we welcome submissions for this Special Issue that provide molecular evidence to clarify how dietary polyphenols and interventions can sustain human health and contribute to alleviating and improving these diseases.

Original research articles, short communications, and reviews are all welcome for submission to this Special Issue.

Dr. Helmut Martin Hügel
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

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Keywords

  • natural products
  • polyphenols
  • biological activity
  • chromatography
  • antioxidants
  • cancer
  • cardiovascular diseases
  • diabetes
  • neurodegenerative disorders

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Published Papers (3 papers)

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Research

14 pages, 7618 KiB  
Article
Simultaneous Electrochemical Detection of Catechol and Hydroquinone Based on a Carbon Nanotube Paste Electrode Modified with Electro-Reduced Graphene Oxide
by Tingfei Chen, Chao Liu, Xiaojun Liu, Chunnan Zhu and Dongyun Zheng
Int. J. Mol. Sci. 2024, 25(18), 9829; https://doi.org/10.3390/ijms25189829 - 11 Sep 2024
Cited by 5 | Viewed by 1189
Abstract
Effectively detecting catechol (CC) and hydroquinone (HQ) simultaneously is crucial for environmental protection and human health monitoring. In the study presented herein, a novel electrochemical sensor for the sensitive simultaneous detection of CC and HQ was constructed based on an electrochemically reduced graphene [...] Read more.
Effectively detecting catechol (CC) and hydroquinone (HQ) simultaneously is crucial for environmental protection and human health monitoring. In the study presented herein, a novel electrochemical sensor for the sensitive simultaneous detection of CC and HQ was constructed based on an electrochemically reduced graphene oxide (ERGO)-modified multi-walled carbon nanotube paste electrode (MWCNTPE). Scanning electron microscopy, X-ray photoelectron spectroscopy, Raman spectroscopy and electrochemical techniques were utilized to characterize the sensing interface and investigate the sensing mechanism. Under the optimal detection conditions, the oxidation peak currents of CC and HQ show a good linear relationship with their concentrations in the range of 0.4–400 μM with a detection limit of 0.083 μM for CC and 0.028 μM for HQ (S/N = 3). Moreover, the sensor exhibits good performance and can be applied successfully in the simultaneous detection of CC and HQ in tap water samples and urine samples with satisfactory results, indicating its promising application prospects. Full article
(This article belongs to the Special Issue Molecular Functions of Polyphenols in Health and Diseases)
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11 pages, 3897 KiB  
Article
Flow and On-Water Synthesis and Cancer Cell Cytotoxicity of Caffeic Acid Phenethyl Amide (CAPA) Derivatives
by Anthony Saucedo, Muppidi Subbarao, Mauricio Jemal, Nakya L. Mesa-Diaz, Jadyn L. Smith, Alexandra Vernaza, Liqin Du and Sean M. Kerwin
Int. J. Mol. Sci. 2024, 25(15), 8051; https://doi.org/10.3390/ijms25158051 - 24 Jul 2024
Cited by 1 | Viewed by 1188
Abstract
Caffeic acid phenethyl ester (CAPE) is a phenolic natural product with a wide range of biological activities, including anticancer activity; however, the ester group of CAPE is metabolically labile. The corresponding amide, CAPA, has improved metabolic stability but limited anticancer activity relative to [...] Read more.
Caffeic acid phenethyl ester (CAPE) is a phenolic natural product with a wide range of biological activities, including anticancer activity; however, the ester group of CAPE is metabolically labile. The corresponding amide, CAPA, has improved metabolic stability but limited anticancer activity relative to CAPE. We report the synthesis using flow and on-water Wittig reaction approaches of five previously reported and five novel CAPA analogues. All of these analogues lack the reactive catechol functionality of CAPA and CAPE. Cytotoxicity studies of CAPE, CAPA, and these CAPA analogues in HeLa and BE(2)-C cells were carried out. Surprisingly, we found that CAPA is cytotoxic against the neuroblastoma BE(2)-C cell line (IC50 = 12 µM), in contrast to the weak activity of CAPA against HeLa cells (IC50 = 112 µM), and the literature reports of the absence of activity for CAPA against a variety of other cancer cell lines. One novel CAPA analogue, 3f, was identified as having cytotoxic activity similar to CAPE in HeLa cells (IC50 = 63 µM for 3f vs. 32 µM for CAPE), albeit with lower activity against BE(2)-C cells (IC50 = 91 µM) than CAPA. A different CAPA analogue, 3g, was found to have similar effects against BE(2)-C cells (IC50 = 92 µM). These results show that CAPA is uniquely active against neuroblastoma cells and that specific CAPA analogues that are predicted to be more metabolically stable than CAPE can reproduce CAPA’s activity against neuroblastoma cells and CAPE’s activity against HeLa cells. Full article
(This article belongs to the Special Issue Molecular Functions of Polyphenols in Health and Diseases)
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21 pages, 1608 KiB  
Article
Innovative Analogs of Unpasteurized Kombucha Beverages: Comparative Analysis of Mint/Nettle Kombuchas, Considering Their Health-Promoting Effect, Polyphenolic Compounds and Chemical Composition
by Patrycja Pawluś and Joanna Kolniak-Ostek
Int. J. Mol. Sci. 2024, 25(14), 7572; https://doi.org/10.3390/ijms25147572 - 10 Jul 2024
Cited by 4 | Viewed by 1670
Abstract
Increasing demand for functional beverages is attracting consumers’ attention and driving research to expand our knowledge of fermentation using symbiotic culture of bacteria and yeast (SCOBY) and demonstrate the health effects of consuming kombucha. The objective of this study was to develop innovative [...] Read more.
Increasing demand for functional beverages is attracting consumers’ attention and driving research to expand our knowledge of fermentation using symbiotic culture of bacteria and yeast (SCOBY) and demonstrate the health effects of consuming kombucha. The objective of this study was to develop innovative recipes for unpasteurized mint/nettle kombucha analogs, and to compare the products obtained under varying conditions in terms of chemical composition, bioactive polyphenols and health-promoting activity. Four variants of kombucha beverages (K1–K4), differing in the addition of sucrose and fermentation temperature, were formulated. The fermentation process provided data indicating the increase of antidiabetic, anti-inflammatory and anticholinergic properties, while a decrease in antioxidant capacity was observed. The content of polyphenolics was the highest on the seventh day of fermentation. A higher fermentation temperature and a larger amount of sucrose accelerated the fermentation process, which may be crucial for shortening the production time of kombucha drinks. Full article
(This article belongs to the Special Issue Molecular Functions of Polyphenols in Health and Diseases)
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