Notch Signaling as a Versatile Regulator of Organ Physiology and Pathology
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (30 April 2021) | Viewed by 10867
Special Issue Editors
Interests: cell fate specification; dental epithelial stem cells; dental genetics; dental pulp stem cells; dental pulp vascular biology; enamel; nerve growth factor; Notch signaling; odontogenesis; tooth innervation; Wnt signaling
Interests: cell fate specification; Notch signaling; embryonic development; stem cell biology; stem cells; imaging; niches; extracellular matrix; integrins
Special Issue Information
Dear Colleagues,
The epithelial and mesenchymal components forming the different organs and tissues of the body possess specific and specialised cell populations that ensure their physiological function in combination with well-established vascular and neuronal networks. All these features are interconnected and functionally linked by complex molecular patterning to maintain intercellular communication and specification of function. The Notch pathway is pivotal in regulating the three-dimensional organisation of organs and tissues and directly participates in cell-to-cell communication, tissue development, pathology and regeneration. Its primordial role in controlling stem cells behaviour, cell proliferation, differentiation and apoptosis makes Notch signalling one of the most fundamental elements in tissue definition. Notch plays an essential role in embryonic development directing a cascade of relevant pathways involved in fate acquisition. Alterations in the Notch signalling pathway during embryonic development generate foetal malformations in humans as a consequence of altered tissue definition. In the adult, aberrant Notch signalling is a hallmark of various diseases, such as Alagille syndrome, CADASIL, Adams–Oliver syndrome, spondylocostal dysostosis and congenital heart disorders, Hajdu–Cheney syndrome, serpentine fibula polycystic kidney syndrome, infantile myofibromatosis and lateral meningocele syndrome, and various cancers.
This Special Issue will be dedicated to compiling the role of the Notch signalling pathway in tissue development, physiology, pathology and regeneration, including studies spanning from craniofacial development and oral tissues determination.
Prof. Dr. Thimios Mitsiadis
Dr. Cristina Porcheri
Guest Editors
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Keywords
- Notch signaling
- Stem cells
- Innervation
- Vasculature
- Organ development
- Tissue regeneration
- Pathologies
- Stem cell niches
- Cell fates
- Single cell analysis
- Notch Cre mice
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