Development and Progression of Non-Alcoholic Fatty Liver Disease: The Role of Advanced Glycation End Products
Abstract
:1. Non-Alcoholic Fatty Liver Disease (NAFLD) and Its Prevalence
2. Factors That Drive NAFLD Progression
3. Advanced Glycation End Products (AGEs): Formation, Metabolism and Their Role in Diseases
4. Advanced Glycation End Products Receptors (RAGEs) and Cell Signaling
5. Role of Hepatic Cells in AGE–RAGE Axis-Induced NAFLD Progression
6. Primary Sources of Advanced Glycation End Products
6.1. Endogenous AGEs
6.2. Exogenous AGEs
7. Role of Advanced Glycation End Products in NAFLD Progression
8. Targeting the AGE/RAGE Axis in NAFLD Progression to Liver Fibrosis
8.1. Impact of Dietary Modifications on NAFLD Progression
8.2. AGE Inhibitors
8.3. Inhibitors of RAGE or AGE/RAGE Binding
9. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Fernando, D.H.; Forbes, J.M.; Angus, P.W.; Herath, C.B. Development and Progression of Non-Alcoholic Fatty Liver Disease: The Role of Advanced Glycation End Products. Int. J. Mol. Sci. 2019, 20, 5037. https://doi.org/10.3390/ijms20205037
Fernando DH, Forbes JM, Angus PW, Herath CB. Development and Progression of Non-Alcoholic Fatty Liver Disease: The Role of Advanced Glycation End Products. International Journal of Molecular Sciences. 2019; 20(20):5037. https://doi.org/10.3390/ijms20205037
Chicago/Turabian StyleFernando, Dinali H., Josephine M. Forbes, Peter W. Angus, and Chandana B. Herath. 2019. "Development and Progression of Non-Alcoholic Fatty Liver Disease: The Role of Advanced Glycation End Products" International Journal of Molecular Sciences 20, no. 20: 5037. https://doi.org/10.3390/ijms20205037