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Development and Progression of Non-Alcoholic Fatty Liver Disease: The Role of Advanced Glycation End Products
Open AccessReview

The Burden of Hepatocellular Carcinoma in Non-Alcoholic Fatty Liver Disease: Screening Issue and Future Perspectives

1
Sezione di Gastroenterologia e Epatologia, PROMISE, University of Palermo, 90127 Palermo, Italy
2
Sezione di Astanteria e MCAU, PROMISE, University of Palermo, 90127 Palermo, Italy
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2019, 20(22), 5613; https://doi.org/10.3390/ijms20225613 (registering DOI)
Received: 30 September 2019 / Revised: 4 November 2019 / Accepted: 6 November 2019 / Published: 9 November 2019
In recent decades, non-alcoholic fatty liver disease (NAFLD) has become the most common liver disease in the Western world, and the occurrence of its complications, such as hepatocellular carcinoma (HCC), has rapidly increased. Obesity and diabetes are considered not only the main triggers for the development of the disease, but also two independent risk factors for HCC. Single nucleotide polymorphisms (such as PNPLA3, TM6SF2 and MBOAT7) are related to the susceptibility to the development of HCC and its progression. Therefore, an appropriate follow-up of these patients is needed for the early diagnosis and treatment of HCC. To date, international guidelines recommend the use of ultrasonography with or without alpha-fetoprotein (AFP) in patients with advanced fibrosis. Furthermore, the use of non-invasive tools could represent a strategy to implement surveillance performance. In this review, we analyzed the main risk factors of NAFLD-related HCC, the validated screening methods and the future perspectives. View Full-Text
Keywords: non-alcoholic fatty liver disease; NAFLD; hepatocellular carcinoma; HCC; PNPLA3; TM6SF2; miRNA; micro RNA; lncRNA; long non-conding RNA non-alcoholic fatty liver disease; NAFLD; hepatocellular carcinoma; HCC; PNPLA3; TM6SF2; miRNA; micro RNA; lncRNA; long non-conding RNA
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Pennisi, G.; Celsa, C.; Giammanco, A.; Spatola, F.; Petta, S. The Burden of Hepatocellular Carcinoma in Non-Alcoholic Fatty Liver Disease: Screening Issue and Future Perspectives. Int. J. Mol. Sci. 2019, 20, 5613.

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