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Nanoparticles(2): From Synthesis to Properties

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Physical Chemistry and Chemical Physics".

Deadline for manuscript submissions: closed (30 December 2023) | Viewed by 8980

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Laboratory of Biochemistry, Institute of Biochemistry and Physiology of Plants and Microorganisms—Subdivision of the Federal State Budgetary Research Institution Saratov Federal Scientific Centre of the Russian Academy of Sciences, 410049 Saratov, Russia
Interests: molecular microbiology; biospectroscopy; FTIR; Raman; biogenic nanoparticles
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Special Issue Information

Dear Colleagues,

Nanoscience and nano(bio)technology have already led to new advances in modern life. Nevertheless, the vast majority of problems related to nanostructured materials remain to be investigated at the molecular level. Among such materials, nanoparticles of different origins (metals, metalloids, chalcogenides, oxides, polymers, etc.) and various methods of synthesis are currently at the forefront of nanoscientific research.

This Special Issue of IJMS will include a collection of expert-level experimental and review-type papers dealing with the synthesis, properties and related applications of nanosized structures of various nature and complexity, with a particular emphasis on the molecular-level analysis of the processes and products involved.

Prof. Alexander A. Kamnev
Guest Editor

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Keywords

  • nanoparticles
  • nanostructures
  • quantum dots
  • synthesis
  • properties
  • functionalization
  • analysis
  • applications

Published Papers (4 papers)

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Research

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15 pages, 4463 KiB  
Article
Antibacterial and Anti-Inflammatory Properties of ZnO Nanoparticles Synthesized by a Green Method Using Sargassum Extracts
by Jose Luis Lopez-Miranda, Gustavo A. Molina, Marlen Alexis González-Reyna, Beatriz Liliana España-Sánchez, Rodrigo Esparza, Rodolfo Silva and Miriam Estévez
Int. J. Mol. Sci. 2023, 24(2), 1474; https://doi.org/10.3390/ijms24021474 - 12 Jan 2023
Cited by 15 | Viewed by 2466
Abstract
The present work shows the synthesis of ZnO nanoparticles through a green method, using sargassum extracts, which provide the reducing and stabilizing compounds. The conditions of the medium in which the reaction was carried out was evaluated, that is, magnetic stirring, ultrasound assisted, [...] Read more.
The present work shows the synthesis of ZnO nanoparticles through a green method, using sargassum extracts, which provide the reducing and stabilizing compounds. The conditions of the medium in which the reaction was carried out was evaluated, that is, magnetic stirring, ultrasound assisted, and resting condition. UV-Vis, FTIR spectroscopy, and X-ray diffraction results confirmed the synthesis of ZnO with nanometric crystal size. The scanning electron microscopy analysis showed that the morphology and size of the particles depends on the synthesis condition used. It obtained particles between 20 and 200 nm in the sample without agitation, while the samples with stirring and ultrasound were 80 nm and 100 nm, respectively. ZnO nanoparticles showed antibacterial activity against Gram-positive S. aureus and Gram-negative P. aeruginosa. A quantitative analysis was performed by varying the concentration of ZnO nanoparticles. In all cases, the antibacterial activity against Gram-positives was greater than against Gram-negatives. Ultrasound-assisted ZnO nanoparticles showed the highest activity, around 99% and 80% for S. aureus and P. aeruginosa, respectively. Similar results were obtained in the study of the anti-inflammatory activity of ZnO nanoparticles; the ultrasound-assisted sample exhibited the highest percentage (93%), even above that shown by diclofenac, which was used as a reference. Therefore, the ZnO nanoparticles synthesized with sargassum extracts have properties that can be used safely and efficiently in the field of biomedicine. Full article
(This article belongs to the Special Issue Nanoparticles(2): From Synthesis to Properties)
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13 pages, 2093 KiB  
Article
Destruction of Lysozyme Amyloid Fibrils Induced by Magnetoferritin and Reconstructed Ferritin
by Jan Gombos, Lucia Balejcikova, Peter Kopcansky, Marianna Batkova, Katarina Siposova, Jozef Kovac, Kristina Zolochevska, Ivo Safarik, Alica Lokajova, Vasil M. Garamus, Dusan Dobrota and Oliver Strbak
Int. J. Mol. Sci. 2022, 23(22), 13926; https://doi.org/10.3390/ijms232213926 - 11 Nov 2022
Cited by 2 | Viewed by 1601
Abstract
Neurodegenerative disorders, including Alzheimer’s disease (AD), Parkinson’s disease (PD), or systemic amyloidosis, are characterized by the specific protein transformation from the native state to stable insoluble deposits, e.g., amyloid plaques. The design of potential therapeutic agents and drugs focuses on the destabilization of [...] Read more.
Neurodegenerative disorders, including Alzheimer’s disease (AD), Parkinson’s disease (PD), or systemic amyloidosis, are characterized by the specific protein transformation from the native state to stable insoluble deposits, e.g., amyloid plaques. The design of potential therapeutic agents and drugs focuses on the destabilization of the bonds in their beta-rich structures. Surprisingly, ferritin derivatives have recently been proposed to destabilize fibril structures. Using atomic force microscopy (AFM) and fluorescence spectrophotometry, we confirmed the destructive effect of reconstructed ferritin (RF) and magnetoferritin (MF) on lysosome amyloid fibrils (LAF). The presence of iron was shown to be the main factor responsible for the destruction of LAF. Moreover, we found that the interaction of RF and MF with LAF caused a significant increase in the release of potentially harmful ferrous ions. Zeta potential and UV spectroscopic measurements of LAF and ferritin derivative mixtures revealed a considerable difference in RF compared to MF. Our results contribute to a better understanding of the mechanism of fibril destabilization by ferritin-like proteins. From this point of view, ferritin derivatives seem to have a dual effect: therapeutic (fibril destruction) and adverse (oxidative stress initiated by increased Fe2+ release). Thus, ferritins may play a significant role in various future biomedical applications. Full article
(This article belongs to the Special Issue Nanoparticles(2): From Synthesis to Properties)
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Review

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26 pages, 1543 KiB  
Review
Mycosynthesis of Metal-Containing Nanoparticles—Synthesis by Ascomycetes and Basidiomycetes and Their Application
by Martin Šebesta, Hana Vojtková, Veronika Cyprichová, Avinash P. Ingle, Martin Urík and Marek Kolenčík
Int. J. Mol. Sci. 2023, 24(1), 304; https://doi.org/10.3390/ijms24010304 - 24 Dec 2022
Cited by 5 | Viewed by 1704
Abstract
Fungi contain species with a plethora of ways of adapting to life in nature. Consequently, they produce large amounts of diverse biomolecules that can be generated on a large scale and in an affordable manner. This makes fungi an attractive alternative for many [...] Read more.
Fungi contain species with a plethora of ways of adapting to life in nature. Consequently, they produce large amounts of diverse biomolecules that can be generated on a large scale and in an affordable manner. This makes fungi an attractive alternative for many biotechnological processes. Ascomycetes and basidiomycetes are the most commonly used fungi for synthesis of metal-containing nanoparticles (NPs). The advantages of NPs created by fungi include the use of non-toxic fungus-produced biochemicals, energy efficiency, ambient temperature, pressure conditions, and the ability to control and tune the crystallinity, shape, and size of the NPs. Furthermore, the presence of biomolecules might serve a dual function as agents in NP formation and also capping that can tailor the (bio)activity of subsequent NPs. This review summarizes and reviews the synthesis of different metal, metal oxide, metal sulfide, and other metal-based NPs mediated by reactive media derived from various species. The phyla ascomycetes and basidiomycetes are presented separately. Moreover, the practical application of NP mycosynthesis, particularly in the fields of biomedicine, catalysis, biosensing, mosquito control, and precision agriculture as nanofertilizers and nanopesticides, has been studied so far. Finally, an outlook is provided, and future recommendations are proposed with an emphasis on the areas where mycosynthesized NPs have greater potential than NPs synthesized using physicochemical approaches. A deeper investigation of the mechanisms of NP formation in fungi-based media is needed, as is a focus on the transfer of NP mycosynthesis from the laboratory to large-scale production and application. Full article
(This article belongs to the Special Issue Nanoparticles(2): From Synthesis to Properties)
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29 pages, 2997 KiB  
Review
Mycosynthesis of Metal-Containing Nanoparticles—Fungal Metal Resistance and Mechanisms of Synthesis
by Martin Šebesta, Hana Vojtková, Veronika Cyprichová, Avinash P. Ingle, Martin Urík and Marek Kolenčík
Int. J. Mol. Sci. 2022, 23(22), 14084; https://doi.org/10.3390/ijms232214084 - 15 Nov 2022
Cited by 16 | Viewed by 2264
Abstract
In the 21st century, nanomaterials play an increasingly important role in our lives with applications in many sectors, including agriculture, biomedicine, and biosensors. Over the last two decades, extensive research has been conducted to find ways to synthesise nanoparticles (NPs) via mediation with [...] Read more.
In the 21st century, nanomaterials play an increasingly important role in our lives with applications in many sectors, including agriculture, biomedicine, and biosensors. Over the last two decades, extensive research has been conducted to find ways to synthesise nanoparticles (NPs) via mediation with fungi or fungal extracts. Mycosynthesis can potentially be an energy-efficient, highly adjustable, environmentally benign alternative to conventional physico-chemical procedures. This review investigates the role of metal toxicity in fungi on cell growth and biochemical levels, and how their strategies of resistance, i.e., metal chelation, biomineral formation, biosorption, bioaccumulation, compartmentalisation, and efflux of metals from cells, contribute to the synthesis of metal-containing NPs used in different applications, e.g., biomedical, antimicrobial, catalytic, biosensing, and precision agriculture. The role of different synthesis conditions, including that of fungal biomolecules serving as nucleation centres or templates for NP synthesis, reducing agents, or capping agents in the synthesis process, is also discussed. The authors believe that future studies need to focus on the mechanism of NP synthesis, as well as on the influence of such conditions as pH, temperature, biomass, the concentration of the precursors, and volume of the fungal extracts on the efficiency of the mycosynthesis of NPs. Full article
(This article belongs to the Special Issue Nanoparticles(2): From Synthesis to Properties)
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