Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
8.1
4.9
Journals
IJMS
Special Issues
The Role of Estrogen Receptors in Health and Diseases
ijms-logo
Submit to IJMS Review for IJMS Propose a Special Issue

Journal Menu

► Journal Menu

Journal Browser

► Journal Browser
share announcement

The Role of Estrogen Receptors in Health and Diseases

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: closed (20 December 2024) | Viewed by 7221

Special Issue Editors

Prof. Dr. Oliver Treeck

E-Mail Website
Guest Editor
Department of Gynecology and Obstetrics I, University Medical Center Regensburg, 93053 Regensburg, Germany
Interests: estrogen receptors; ER and GPER-1 signaling; breast and ovarian cancer; non-coding RNAs
Special Issues, Collections and Topics in MDPI journals
Dr. Maciej Iek Skrzypczak

E-Mail Website
Guest Editor
Second Department of Gynecology, Medical University of Lublin, 20-090 Lublin, Poland
Interests: estrogen receptors; endometrial cancer; ovarian cancer; breast cancer; sarcomas; PCOS; endometriosis; non-coding RNAs
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The estrogen receptors ERα, ERβ, and the G‑protein‑coupled estrogen receptor (GPER) are expressed in various tissues, e.g., in the brain, liver, bone, breast, colon, skin, salivary gland, and the tissues of the female reproductive tract. They mediate the effects of estrogens in many physiological and pathophysiological processes via different molecular mechanisms, which finally result in gene regulation.

The wide expression of these receptors is the background for this Special Issue. Whereas the function of ERa for example in breast cancer has been extensively studied, there remain open questions regarding the role of both nuclear ERs and of GPER-1 in different physiological processes and in the pathogenesis of various diseases.

This Special Issue of IJMS is thus calling for original work or comprehensive review articles on the role of ERa, ERb, and GPER-1 (A) in classical estrogen-dependent tissues of the female reproduction system, such as tumors of the ovary and endometrium or benign female reproductive disorders such as endometriosis or the polycystic ovary syndrome and (B) also addresses novel insights in the function of these receptors in the physiology and pathobiology of other tissues, which have classically not been considered to be estrogen-responsive. In addition to new aspects of their physiological function, novel insights in the role of these receptors in various diseases, elucidating putative tissue-specific pathways, have the potential to identify potential new biomarkers or therapy targets.

Suitable topics include but are not limited to:

  • The role of ERa, ERb, and GPER-1 in the pathogenesis of diseases of tissues expressing at least one of these receptors;
  • Novel insights in the physiological function of estrogen receptors in tissues expressing one or more of these receptors.

Prof. Dr. Oliver Treeck
Prof. Dr. Maciej Iek Skrzypczak
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

 

Keywords

  • estrogen receptors
  • physiology
  • pathobiology
  • cancer
  • benign diseases and disorders
 

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (3 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

Jump to: Review

31 pages, 6493 KiB  
Article
Epigenetic Modulation of GPER Expression in Gastric and Colonic Smooth Muscle of Male and Female Non-Obese Diabetic (NOD) Mice: Insights into H3K4me3 and H3K27ac Modifications
by Juanita C. Hixon, Jatna I. Rivas Zarete, Jason White, Mariline Hilaire, Aliyu Muhammad, Abdurrahman Pharmacy Yusuf, Benjamin Adu-Addai, Clayton C. Yates and Sunila Mahavadi
Int. J. Mol. Sci. 2024, 25(10), 5260; https://doi.org/10.3390/ijms25105260 - 11 May 2024
Viewed by 2485
Abstract
Type 1 diabetes (T1D) affects gastrointestinal (GI) motility, favoring gastroparesis, constipation, and fecal incontinence, which are more prevalent in women. The mechanisms are unknown. Given the G-protein-coupled estrogen receptor’s (GPER) role in GI motility, we investigated sex-related diabetes-induced epigenetic changes in GPER. We [...] Read more.
Type 1 diabetes (T1D) affects gastrointestinal (GI) motility, favoring gastroparesis, constipation, and fecal incontinence, which are more prevalent in women. The mechanisms are unknown. Given the G-protein-coupled estrogen receptor’s (GPER) role in GI motility, we investigated sex-related diabetes-induced epigenetic changes in GPER. We assessed GPER mRNA and protein expression levels using qPCR and Western blot analyses, and quantified the changes in nuclear DNA methyltransferases and histone modifications (H3K4me3, H3Ac, and H3K27Ac) by ELISA kits. Targeted bisulfite and chromatin immunoprecipitation assays were used to evaluate DNA methylation and histone modifications around the GPER promoter by chromatin immunoprecipitation assays in gastric and colonic smooth muscle tissues of male and female control (CTR) and non-obese diabetic (NOD) mice. GPER expression was downregulated in NOD, with sex-dependent variations. In the gastric smooth muscle, not in colonic smooth muscle, downregulation coincided with differences in methylation ratios between regions 1 and 2 of the GPER promoter of NOD. DNA methylation was higher in NOD male colonic smooth muscle than in NOD females. H3K4me3 and H3ac enrichment decreased in NOD gastric smooth muscle. H3K4me3 levels diminished in the colonic smooth muscle of NOD. H3K27ac levels were unaffected, but enrichment decreased in NOD male gastric smooth muscle; however, it increased in the NOD male colonic smooth muscle and decreased in the female NOD colonic smooth muscle. Male NOD colonic smooth muscle exhibited decreased H3K27ac levels, not female, whereas female NOD colonic smooth muscle demonstrated diminished enrichment of H3ac at the GPER promoter, contrary to male NOD. Sex-specific epigenetic mechanisms contribute to T1D-mediated suppression of GPER expression in the GI tract. These insights advance our understanding of T1D complications and suggest promising avenues for targeted therapeutic interventions. Full article
(This article belongs to the Special Issue The Role of Estrogen Receptors in Health and Diseases)
►▼ Show Figures

Figure 1

22 pages, 3980 KiB  
Article
Expression Analysis of Lipocalin 2 (LCN2) in Reproductive and Non-Reproductive Tissues of Esr1-Deficient Mice
by Jan C. Kessel, Ralf Weiskirchen and Sarah K. Schröder
Int. J. Mol. Sci. 2023, 24(11), 9280; https://doi.org/10.3390/ijms24119280 - 25 May 2023
Cited by 6 | Viewed by 2583
Abstract
Estrogen receptor alpha (ERα) is widely expressed in reproductive organs, but also in non-reproductive tissues of females and males. There is evidence that lipocalin 2 (LCN2), which has diverse immunological and metabolic functions, is regulated by ERα in adipose tissue. However, in many [...] Read more.
Estrogen receptor alpha (ERα) is widely expressed in reproductive organs, but also in non-reproductive tissues of females and males. There is evidence that lipocalin 2 (LCN2), which has diverse immunological and metabolic functions, is regulated by ERα in adipose tissue. However, in many other tissues, the impact of ERα on LCN2 expression has not been studied yet. Therefore, we used an Esr1-deficient mouse strain and analyzed LCN2 expression in reproductive (ovary, testes) and non-reproductive tissues (kidney, spleen, liver, lung) of both sexes. Tissues collected from adult wild-type (WT) and Esr1-deficient animals were analyzed by immunohistochemistry, Western blot analysis, and RT-qPCR for Lcn2 expression. In non-reproductive tissues, only minor genotype- or sex-specific differences in LCN2 expression were detected. In contrast, significant differences in LCN2 expression were observed in reproductive tissues. Particularly, there was a strong increase in LCN2 in Esr1-deficient ovaries when compared to WTs. In summary, we found an inverse correlation between the presence of ERα and the expression of LCN2 in testes and ovaries. Our results provide an important basis to better understand LCN2 regulation in the context of hormones and in health and disease. Full article
(This article belongs to the Special Issue The Role of Estrogen Receptors in Health and Diseases)
►▼ Show Figures

Graphical abstract

Review

Jump to: Research

16 pages, 325 KiB  
Review
Effects of Endocrine Interventions Targeting ERα or PR on Breast Cancer Risk in the General Population and Carriers of BRCA1/2 Pathogenic Variants
by Deborah Huber, Maria Hatzipanagiotou, Susanne Schüler-Toprak, Olaf Ortmann and Oliver Treeck
Int. J. Mol. Sci. 2024, 25(11), 5894; https://doi.org/10.3390/ijms25115894 - 28 May 2024
Cited by 1 | Viewed by 1368
Abstract
There is evidence suggesting that endocrine interventions such as hormone replacement therapy and hormonal contraception can increase breast cancer (BC) risk. Sexual steroid hormones like estrogens have long been known for their adverse effects on BC development and progression via binding to estrogen [...] Read more.
There is evidence suggesting that endocrine interventions such as hormone replacement therapy and hormonal contraception can increase breast cancer (BC) risk. Sexual steroid hormones like estrogens have long been known for their adverse effects on BC development and progression via binding to estrogen receptor (ER) α. Thus, in recent years, endocrine interventions that include estrogens have been discussed more and more critically, and their impact on different BC subgroups has increasingly gained interest. Carriers of pathogenic variants in BRCA1/2 genes are known to have a high risk of developing BC and ovarian cancer. However, there remain open questions to what extent endocrine interventions targeting ERα or the progesterone receptor further increase cancer risk in this subgroup. This review article aims to provide an overview and update on the effects of endocrine interventions on breast cancer risk in the general population in comparison to BRCA1/2 mutation carriers. Finally, future directions of research are addressed, to further improve the understanding of the effects of endocrine interventions on high-risk pathogenic variant carriers. Full article
(This article belongs to the Special Issue The Role of Estrogen Receptors in Health and Diseases)
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-3
Back to TopTop