The Role of Estrogen Receptors in Health and Diseases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (20 December 2024) | Viewed by 7336
Special Issue Editors
Interests: estrogen receptors; ER and GPER-1 signaling; breast and ovarian cancer; non-coding RNAs
Special Issues, Collections and Topics in MDPI journals
Interests: estrogen receptors; endometrial cancer; ovarian cancer; breast cancer; sarcomas; PCOS; endometriosis; non-coding RNAs
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The estrogen receptors ERα, ERβ, and the G‑protein‑coupled estrogen receptor (GPER) are expressed in various tissues, e.g., in the brain, liver, bone, breast, colon, skin, salivary gland, and the tissues of the female reproductive tract. They mediate the effects of estrogens in many physiological and pathophysiological processes via different molecular mechanisms, which finally result in gene regulation.
The wide expression of these receptors is the background for this Special Issue. Whereas the function of ERa for example in breast cancer has been extensively studied, there remain open questions regarding the role of both nuclear ERs and of GPER-1 in different physiological processes and in the pathogenesis of various diseases.
This Special Issue of IJMS is thus calling for original work or comprehensive review articles on the role of ERa, ERb, and GPER-1 (A) in classical estrogen-dependent tissues of the female reproduction system, such as tumors of the ovary and endometrium or benign female reproductive disorders such as endometriosis or the polycystic ovary syndrome and (B) also addresses novel insights in the function of these receptors in the physiology and pathobiology of other tissues, which have classically not been considered to be estrogen-responsive. In addition to new aspects of their physiological function, novel insights in the role of these receptors in various diseases, elucidating putative tissue-specific pathways, have the potential to identify potential new biomarkers or therapy targets.
Suitable topics include but are not limited to:
- The role of ERa, ERb, and GPER-1 in the pathogenesis of diseases of tissues expressing at least one of these receptors;
- Novel insights in the physiological function of estrogen receptors in tissues expressing one or more of these receptors.
Prof. Dr. Oliver Treeck
Prof. Dr. Maciej Iek Skrzypczak
Guest Editors
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Keywords
- estrogen receptors
- physiology
- pathobiology
- cancer
- benign diseases and disorders
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