Gestational Diabetes Mellitus: Molecular Insights into Pathophysiology, Management and Therapy
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 20 September 2025 | Viewed by 417
Special Issue Editor
Special Issue Information
Dear Colleagues,
It has been more than 50 years since J. Pedersen proposed the hypothesis according to which hyperglycemia associated with diabetes in pregnancy triggers a cascade of events leading to fetal hyperinsulinemia, and as a result excessive fetal growth. Gestational diabetes mellitus (GDM) constitutes one of the forms of impaired glucose tolerance and is diagnosed for the first time during pregnancy. The condition occurs in ca. 5-15% of pregnant women, mostly predisposed, and is associated with multiple maternal-fetal complications including fetal macrosomia, preeclampsia and polyhydramnios. Moreover, existing evidence suggests the effects of GDM extend beyond the gestation period for both the mother and child, hence implicating it's role in future health programming. It is, therefore, obvious that genetic mechanisms play an important role in GDM pathogenesis and occurrence of certain diabetic complications. Gene mutations, post-transcriptional and post-translational modifications are some of the examples of alterations underlying pathologies present in GDM, patient’s responsiveness to therapy as well as maternal-fetal health programming.
This Special Issue is dedicated to all those above-mentioned changes observed on the molecular level and associated with diabetic environment in pregnancy. Original and review papers evaluating the role of genetics in GDM are welcome.
Dr. Paweł Jan Stanirowski
Guest Editor
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Keywords
- GDM pathogenesis
- health programming
- pharmacogenomics
- life-style interventions
- fetal growth disorders
- preeclampsia
- polyhydramnios
- placental origin of disease
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