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Cellular and Molecular Mechanisms of Liver Regeneration

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: closed (31 October 2020) | Viewed by 2583

Special Issue Editor


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Guest Editor
Yokohama City University, Japan

Special Issue Information

Dear Colleagues,

Liver regeneration is important for the maintenance of liver functional mass for homeostasis and in diseases. The regeneration of the liver is an interesting topic that has been investigated extensively over many decades. Liver regeneration is a complex process involving intricate signals to and from different cell types. When the remaining hepatocytes are competent, hepatocytes are the main cell type responsible for supporting liver size homeostasis and regeneration. In a chronically or severely injured liver, hepatocytes may enter a state of replicative senescence, and liver transplantation remains the only definitive treatment for patients with end-stage liver injury. However, donor shortages result in high mortality rates among patients on waiting lists, suggesting there is an urgent need to develop alternate approaches. Many scientists have searched for drugs that promote liver regeneration. Unfortunately, a clinically usable drug has not yet been developed. There is also active research into transplanting stem cells to regenerate the liver. Studies applying ae direct reprogramming method to regenerate the liver are also being actively conducted. In this Special Issue, we would like to focus on research that promotes liver regeneration and leads to the development of new treatment methods that do not rely on liver transplantation.

Dr. Soichiro Murata
Guest Editor

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Keywords

  • liver regeneration
  • stem cell
  • low molecular weight compound
  • direct reprogramming
  • cytokine

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Published Papers (1 paper)

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Research

13 pages, 2978 KiB  
Article
Inhaled Argon Impedes Hepatic Regeneration after Ischemia/Reperfusion Injury in Rats
by Sophia M. Schmitz, Henriette Dohmeier, Christian Stoppe, Patrick H. Alizai, Sandra Schipper, Ulf P. Neumann, Mark Coburn and Tom F. Ulmer
Int. J. Mol. Sci. 2020, 21(15), 5457; https://doi.org/10.3390/ijms21155457 - 30 Jul 2020
Cited by 6 | Viewed by 2311
Abstract
Organoprotective effects of noble gases are subject of current research. One important field of interest is the effect of noble gases on hepatic regenerative capacity. For the noble gas argon, promising studies demonstrated remarkable experimental effects in neuronal and renal cells. The aim [...] Read more.
Organoprotective effects of noble gases are subject of current research. One important field of interest is the effect of noble gases on hepatic regenerative capacity. For the noble gas argon, promising studies demonstrated remarkable experimental effects in neuronal and renal cells. The aim of this study was to investigate the effects of argon on the regenerative capacity of the liver after ischemia/reperfusion injury (IRI). Male, Sprague-Dawley rats underwent hepatic IRI by clamping of the hepatic artery. Expression of hepatoproliferative genes (HGF, IL-1β, IL-6, TNF), cell cycle markers (BrdU, TUNEL, Ki-67), and liver enzymes (ALT, AST, Bilirubin, LDH) were assessed 3, 36, and 96 h after IRI. Expression of IL-1β and IL-6 was significantly higher after argon inhalation after 36 h (IL-1β 5.0 vs. 8.7 fold, p = 0.001; IL-6 9.6 vs. 19.1 fold, p = 0.05). Ki-67 was higher in the control group compared to the argon group after 36 h (214.0 vs. 38.7 positive cells/1000 hepatocytes, p = 0.045). Serum levels of AST and ALT did not differ significantly between groups. Our data indicate that argon inhalation has detrimental effects on liver regeneration after IRI as measured by elevated levels of the proinflammatory cytokines IL-1β and IL-6 after 36 h. In line with these results, Ki-67 is decreased in the argon group, indicating a negative effect on liver regeneration in argon inhalation. Full article
(This article belongs to the Special Issue Cellular and Molecular Mechanisms of Liver Regeneration)
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