Cellular and Molecular Mechanisms of Liver Regeneration
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (31 October 2020) | Viewed by 2583
Special Issue Editor
Special Issue Information
Dear Colleagues,
Liver regeneration is important for the maintenance of liver functional mass for homeostasis and in diseases. The regeneration of the liver is an interesting topic that has been investigated extensively over many decades. Liver regeneration is a complex process involving intricate signals to and from different cell types. When the remaining hepatocytes are competent, hepatocytes are the main cell type responsible for supporting liver size homeostasis and regeneration. In a chronically or severely injured liver, hepatocytes may enter a state of replicative senescence, and liver transplantation remains the only definitive treatment for patients with end-stage liver injury. However, donor shortages result in high mortality rates among patients on waiting lists, suggesting there is an urgent need to develop alternate approaches. Many scientists have searched for drugs that promote liver regeneration. Unfortunately, a clinically usable drug has not yet been developed. There is also active research into transplanting stem cells to regenerate the liver. Studies applying ae direct reprogramming method to regenerate the liver are also being actively conducted. In this Special Issue, we would like to focus on research that promotes liver regeneration and leads to the development of new treatment methods that do not rely on liver transplantation.
Dr. Soichiro Murata
Guest Editor
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Keywords
- liver regeneration
- stem cell
- low molecular weight compound
- direct reprogramming
- cytokine
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