Pathophysiological and Molecular Insights into Heart Failure: From Diagnosis to Therapy
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (31 December 2024) | Viewed by 5014
Special Issue Editor
Interests: cardiology; heart failure; pharmacology; therapy; genetic; coronary microvascular dysfunction
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Heart failure (HF) is a complex and multifaceted syndrome that is associated with a progressive and multisystemic involvement leading, in the advanced stages, to multiorgan dysfunction. It is characterized by high mortality and morbidity rates. Several pathways are involved in HF pathophysiology, representing pivotal therapeutic targets. However, new molecules have been identified as potential diagnostic, prognostic and therapeutic biomarkers. In this case, microRNAs have been identified as promising tools, while other myocardial markers, such as Brain Natriuretic Peptides, High Sensitivity Cardiac Troponins have shown prognostic power to help cardiologists for the management of HF patients. In particular, they may be useful to guide the up-titration of pharmacological therapy and to identify a subclinical HF worsening requiring therapy modification or more advanced strategies of treatment.
Besides the pharmacological treatment, several trials have shown the benefit of implantable electrical therapeutical technology, such as cardiac resynchronization therapy and cardiac contractility modulation, in order to reduce hospitalization due to HF and CV mortality. They also demonstrated to be effective in improving the life quality of HF patients.
To better highlight the recent advances in HF, this Special Issue will focus on new findings regarding pathophysiology, molecular and genetic aspects of HF in terms of diagnostic, prognostic and therapeutic tools. Original articles, reviews of current literature and original perspectives on this topic will be taken into account.
Dr. Paolo Severino
Guest Editor
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Keywords
- heart failure
- pathophysiology
- diagnosis
- pharmacological therapy
- device therapy
- microRNAs
- myocardial biomarkers
- molecular pathways
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