Special Issue "Inflammation and Cancer"
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (31 March 2017)
A printed edition of this Special Issue is available here.
Prof. Dr. Takuji Tanaka
Prof. Dr. Masahito Shimizu
Based on the data that are now available in the GLOBOCAN series of the IARC, there were 14.1 million new cases of cancer and 8.2 million cancer deaths in 2012. Among epithelial malignancies, some cancers have strong links to chronic inflammation and develop in the background of uncontrolled chronic inflammation. Although the mechanisms have not fully been elucidated, reactive oxygen and nitrogen species produced by inflammatory cells may cause DNA damage and mutations. These inflammatory cells are also able to produce and secrete a variety of cytokines and chemokines, some of which are known to affect tumor growth, metastasis, and angiogenesis.
The association between chronic inflammation and cancer is not a new concept. In 1863, Dr. Rudolf Virchow noticed, and first wrote about, the presence of leukocytes in neoplastic tissues. He later hypothesized that carcinogenesis could occur at sites of chronic inflammation and that uncontrolled chronic inflammation provides a favorable environment for cancer to form and grow. Today, oncologic data strongly support Virchow's intuition, confirming that some malignancies do not arise from infection and uncontrolled chronic inflammation. The last two decades of the 20th century were marked by the breathtaking evolution of molecular techniques in biology that consolidated the theoretical foundation of inflammation-associated carcinogenesis. Intriguingly, for both infection experts and oncologists, systemic inflammation appears to influence different phases of oncogenesis through different mechanisms.
In this light, this Special Issue entitled, “Inflammation and Cancer”, is well-timed to say the least, and provides a practical appreciation for the many biochemical, molecular, immunological, and cellular mechanisms shared by cancer and inflammatory processes.
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- gut microbiota
- insulin resistance
- molecular biology
- adipose tissue
- clinical trials