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Int. J. Mol. Sci. 2017, 18(5), 908;

Prevention of Colorectal Cancer by Targeting Obesity-Related Disorders and Inflammation

Department of Informative Clinical Medicine, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan
Department of Gastroenterology, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan
Department of Pathological Diagnosis, Gifu Municipal Hospital, Gifu 500-8513, Japan
Author to whom correspondence should be addressed.
Academic Editor: Terrence Piva
Received: 24 March 2017 / Revised: 17 April 2017 / Accepted: 20 April 2017 / Published: 26 April 2017
(This article belongs to the Special Issue Inflammation and Cancer)
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Colorectal cancer is a major healthcare concern worldwide. Many experimental and clinical studies have been conducted to date to discover agents that help in the prevention of this disease. Chronic inflammation in colonic mucosa and obesity, and its related metabolic abnormalities, are considered to increase the risk of colorectal cancer. Therefore, treatments targeting these factors might be a promising strategy to prevent the development of colorectal cancer. Among a number of functional foods, various phytochemicals, including tea catechins, which have anti-inflammatory and anti-obesity properties, and medicinal agents that ameliorate metabolic disorders, might also be beneficial in the prevention of colorectal cancer. In this review article, we summarize the strategies for preventing colorectal cancer by targeting obesity-related disorders and inflammation through nutraceutical and pharmaceutical approaches, and discuss the mechanisms of several phytochemicals and medicinal drugs used in basic and clinical research, especially focusing on the effects of green tea catechins. View Full-Text
Keywords: colorectal cancer; chemoprevention; inflammation; obesity; green tea colorectal cancer; chemoprevention; inflammation; obesity; green tea

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Shirakami, Y.; Ohnishi, M.; Sakai, H.; Tanaka, T.; Shimizu, M. Prevention of Colorectal Cancer by Targeting Obesity-Related Disorders and Inflammation. Int. J. Mol. Sci. 2017, 18, 908.

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