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Neuro-Molecular Pathogenetic Mechanisms of Sudden Infant Death Syndrome (SIDS) and Other Infant Neurodevelopmental Disorders

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".

Deadline for manuscript submissions: 31 May 2024 | Viewed by 177

Special Issue Editor

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Guest Editor
“Lino Rossi” Research Center for the Study and Prevention of Unexpected Perinatal Death and SIDS, Department of Biomedical, Surgical and Dental Sciences, University of Milan, 20122 Milan, Italy
Interests: neuropathology; autonomic nervous system; brain development; neurotransmitters; molecular neurology; SIDS
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Special Issue Information

Dear Colleagues,

Sudden Infant Death Syndrome (SIDS) is the leading cause of death among infants in the first year of age, with a frequency of 1 every 750–1000 live births. This syndrome refers to the sudden unexpected death of an infant under 1 year of age that remains unexplained after a thorough investigation, including a complete autopsy, detailed review of the circumstances of death and clinical history.

Even if the pathogenetic mechanism of SIDS has not yet been determined, neuropathology seems to be a consistent substrate. Subtle developmental abnormalities of brainstem nuclei checking the vital functions have been highlighted, frequently related to environmental risk factors (such as cigarette smoke, air pollution, pesticides, etc.). Exogenous toxic factors can in fact interact in complex ways with the genetic constitution of the infant, leading to polymorphisms and/or mutations of specific genes (such as polymorphisms of the serotonin transporter gene 5-HTT, the regulator of the synaptic serotonin concentration, frequently found in SIDS associated with hypoplasia of the raphe nuclei or mutations of genes required for cardiorespiratory activity that can predispose patients to SIDS).

Another aim of this proposal is to deepen the knowledge regarding developmental brain dysfunctions of the autonomic control that can be found in additional infant syndromes, such as Rett syndrome, cyclin-dependent kinase-like 5 (CDKL5) deficiency disorder, Pitt–Hopkins syndrome, congenital central hypoventilation syndrome (CCHS), and GRIN1-related neurodevelopmental disorder, characterized by frequent association with insufficient expression or mutations of specific genes in the context of the interactions with environmental risk factors (e.g. early exposure to smoking, air and water pollution, pesticides, food contamination).

The aim of this Special Issue is to collect new contributions useful to explain the pathogenesis of SIDS and other childhood neurodevelopmental disorders and consequently provide useful data for planning effective prevention strategies.

Expert researchers in this field are encouraged to submit high-quality original research articles and reviews aimed to widen the current knowledge on the neuropathological and molecular mechanisms underlying these nervous developmental disorders, also considering the correlations with possible risk factors.

Prof. Dr. Anna Maria Lavezzi
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • congenital central hypoventilation syndrome (CCHS)
  • cyclin-dependent kinase-like 5 (CDKL5)) deficiency disorder
  • GRIN1-related neurodevelopmental disorder 
  • SIDS
  • neuropathology
  • neurodevelopmental alterations
  • genetic polymorphisms
  • mutations
  • pollutants
  • Pitt-Hopkins syndrome
  • Rett syndrome
  • risk factors

Published Papers

This special issue is now open for submission.
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