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Natural Compounds and Strategies for Developing Novel Anti-inflammatory Drugs

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pharmacology".

Deadline for manuscript submissions: 30 July 2024 | Viewed by 556

Special Issue Editor


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Guest Editor
Department of Science and Technology, University of Sannio, 82100 Benevento, Italy
Interests: natural compounds; nanoparticles; drug delivery; natural anti-inflammatory agents; neuroblastoma; colorectal cancer

Special Issue Information

Dear Colleagues,

Natural products are mainly secondary metabolites produced by plants, microorganisms, and animals that can be used as a medicine in modern drug discovery but require a series of structural changes to serve as a drug. The chemical structure of the natural product’s molecule is used as a starting point for chemical modifications in order to improve its selectivity, potency, pharmacodynamics, and pharmacokinetic parameters.

This Special Issue, entitled “Natural Compounds and Strategies for Developing Novel Anti-inflammatory Drugs”, of the International Journal of Molecular Sciences will focus on the methodology and results obtained in the process of the optimization of anti-inflammatory drugs using natural compounds for in vitro or clinical testing.

Since IJMS is a journal of molecular science, pure clinical or model studies will not be suitable for this journal. But clinical or pure model submissions with biomolecular experiments are welcomed.

Dr. Rosanna Filosa
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • anti-inflammatory drugs
  • natural compounds
  • bioactive compounds
  • drug design
  • natural anti-inflammatory agents

Published Papers (1 paper)

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Research

11 pages, 5808 KiB  
Article
The Inhibition Activity of Natural Methoxyflavonoid from Inula britannica on Soluble Epoxide Hydrolase and NO Production in RAW264.7 Cells
by Jang Hoon Kim, Kyung-Sook Han, Eun-Song Lee, Yong-Goo Kim, Yong-Il Kim, Byoung Ok Cho and Ik Soo Lee
Int. J. Mol. Sci. 2024, 25(8), 4357; https://doi.org/10.3390/ijms25084357 - 15 Apr 2024
Viewed by 332
Abstract
Soluble epoxide hydrolase (sEH) is an enzyme targeted for the treatment of inflammation and cardiovascular diseases. Activated inflammatory cells produce nitric oxide (NO), which induces oxidative stress and exacerbates inflammation. We identify an inhibitor able to suppress sEH and thus NO production. Five [...] Read more.
Soluble epoxide hydrolase (sEH) is an enzyme targeted for the treatment of inflammation and cardiovascular diseases. Activated inflammatory cells produce nitric oxide (NO), which induces oxidative stress and exacerbates inflammation. We identify an inhibitor able to suppress sEH and thus NO production. Five flavonoids 15 isolated from Inula britannica flowers were evaluated for their abilities to inhibit sEH with IC50 values of 12.1 ± 0.1 to 62.8 ± 1.8 µM and for their effects on enzyme kinetics. A simulation study using computational chemistry was conducted as well. Furthermore, five inhibitors (15) were confirmed to suppress NO levels at 10 µM. The results showed that flavonoids 15 exhibited inhibitory activity in all tests, with compound 3 exhibiting the most significant efficacy. Thus, in the development of anti-inflammatory inhibitors, compound 3 is a promising natural candidate. Full article
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