Advanced Research Progress of Blood-Brain Barrier

Dear Colleagues,

The blood–brain barrier (BBB) is a complex dynamic interface between the blood and the central nervous system (CNS), which plays the critical role of regulating the homeostatic, nutritive and immune environments of the CNS, as well as the exchange of informational molecules between the CNS and periphery. BBB impairments have been strongly associated with the onset and progression of many neurological disorders, while also representing a major hindrance to CNS drug delivery. There is a need to further our understanding of the molecular mechanisms regulating BBB functions, including its physiological and pathological responses to bloodborne substances and xenobiotics, which also comprise putative brain-targeting therapeutics.

This Special Issue of the International Journal of Molecular Sciences welcomes both original research articles and review papers that deal with the molecular mechanisms underpinning the BBB in health and disease, as well as recent advances in experimental in vitro technologies that can further our understanding of the BBB and aid the process of CNS drug discovery.

Dr. Cucullo Luca
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• blood–brain barrier
• endothelium
• glia
• drug discovery
• physiology, in vitro
• mechanism
• neurovascular
• microcapillary
• permeability