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New Biomarkers and Therapy for Cancer Stem Cells
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New Biomarkers and Therapy for Cancer Stem Cells

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: closed (31 March 2024) | Viewed by 5346

Special Issue Editor

Prof. Dr. Pyung-Hwan Kim

E-Mail Website
Guest Editor
Department of Biomedical Laboratory Science, Konyang University, Daejeon 35365, Republic of Korea
Interests: engineered stem cells

Special Issue Information

Dear Colleagues,

Cancer is still one of the most difficult diseases to treat despite the advancement of innovative medical technology, such as from first-generation chemotherapy to third-generation cancer immunotherapy. The recurrence of cancer is known to be caused by cancer stem cells. For complete cancer treatment, both cancer cells and cancer stem cells must induce death. However, cancer stem cells exist with very little population among cancer cells, and biomarkers to identify them have limitations in clinical application due to heterogeneity and plasticity between people. Therefore, a targeting strategy is needed along with the discovery of new biomarkers to treat cancer stem cells and diagnose and determine prognosis. This Special Issue addresses a wide range of topics linked with the research on biological functions according to the discovery of new biomarkers for cancer stem cells and new treatment strategies for an application study using them. Recent research and new advancements in this field and other related topics are welcome.

Prof. Dr. Pyung-Hwan Kim
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomarkers
  • cancer stem cells
  • targeted therapy

Published Papers (3 papers)

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Research

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20 pages, 8016 KiB  
Article
Active Targeting of Versatile Nanocomplex Using the Novel Biomarker of Breast Cancer Stem Cells
by Eun-Young Koh, Keun-Sik Kim, Hee-Bin Park, Jong-Seok Kim and Pyung-Hwan Kim
Int. J. Mol. Sci. 2023, 24(1), 685; https://doi.org/10.3390/ijms24010685 - 30 Dec 2022
Cited by 5 | Viewed by 1435
Abstract
Breast cancer in women is one of the most common life-threatening malignancies. Despite of the development for the improved treatment, there are still many limitations to overcome. Among them, cancer stem cells (CSCs) are well known for tumor formation, development, cellular heterogeneity, and [...] Read more.
Breast cancer in women is one of the most common life-threatening malignancies. Despite of the development for the improved treatment, there are still many limitations to overcome. Among them, cancer stem cells (CSCs) are well known for tumor formation, development, cellular heterogeneity, and cancer recurrence. Therefore, to completely cure breast cancer, treatment of both cancer and CSC is required. To selectively target CSCs, we generated a liposome-based smart nano complex using CEACAM 6 (CD66c) antibody (Ab), a novel cell-surface biomarker of breast-derived CSCs (BCSCs) discovered in our previous research. Selective and increased cellular uptake was observed in BCSCs treated with CD66c Ab-conjugated rhodamine-labeled liposomes (CDRHOL) depending on the expression level of CD66c. CD66c Ab-conjugated doxorubicin (DOX)-loaded liposomes (CDDOXL) selectively showed increased cell killing effects in BCSCs with high CD66c expression levels. In an in vivo animal study, CDRHOL showed enhanced accumulation in xenografted BCSC tumors with low delivery into non-target organs. Moreover, mice treated with CDDOXL have assessed the decreased induction ability of immune response by low expression levels of pro-inflammatory cytokines and reduced liver toxicity by histopathological analysis. Finally, the improved antitumor effect of CDDOXL was evaluated in a metastatic BCSC mouse model via systemic administration. Collectively, our study is the first to demonstrate that a multi-functional nano complex using a novel surface biomarker of BCSC may be a more effective therapeutic agent for the treatment of cancer and CSCs. Full article
(This article belongs to the Special Issue New Biomarkers and Therapy for Cancer Stem Cells)
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Review

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43 pages, 1604 KiB  
Review
Deciphering Common Traits of Breast and Ovarian Cancer Stem Cells and Possible Therapeutic Approaches
by Ivan Lučić, Matea Kurtović, Monika Mlinarić, Nikolina Piteša, Ana Čipak Gašparović, Maja Sabol and Lidija Milković
Int. J. Mol. Sci. 2023, 24(13), 10683; https://doi.org/10.3390/ijms241310683 - 26 Jun 2023
Viewed by 1659
Abstract
Breast cancer (BC) and ovarian cancer (OC) are among the most common and deadly cancers affecting women worldwide. Both are complex diseases with marked heterogeneity. Despite the induction of screening programs that increase the frequency of earlier diagnosis of BC, at a stage [...] Read more.
Breast cancer (BC) and ovarian cancer (OC) are among the most common and deadly cancers affecting women worldwide. Both are complex diseases with marked heterogeneity. Despite the induction of screening programs that increase the frequency of earlier diagnosis of BC, at a stage when the cancer is more likely to respond to therapy, which does not exist for OC, more than 50% of both cancers are diagnosed at an advanced stage. Initial therapy can put the cancer into remission. However, recurrences occur frequently in both BC and OC, which are highly cancer-subtype dependent. Therapy resistance is mainly attributed to a rare subpopulation of cells, named cancer stem cells (CSC) or tumor-initiating cells, as they are capable of self-renewal, tumor initiation, and regrowth of tumor bulk. In this review, we will discuss the distinctive markers and signaling pathways that characterize CSC, their interactions with the tumor microenvironment, and the strategies they employ to evade immune surveillance. Our focus will be on identifying the common features of breast cancer stem cells (BCSC) and ovarian cancer stem cells (OCSC) and suggesting potential therapeutic approaches. Full article
(This article belongs to the Special Issue New Biomarkers and Therapy for Cancer Stem Cells)
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14 pages, 1169 KiB  
Review
Protein Posttranslational Modification in Stemness Remodeling and Its Emerging Role as a Novel Therapeutic Target in Gastrointestinal Cancers
by Yifei Wang and Man Tong
Int. J. Mol. Sci. 2023, 24(11), 9173; https://doi.org/10.3390/ijms24119173 - 24 May 2023
Cited by 2 | Viewed by 1676
Abstract
The posttranslational modifications (PTMs) of proteins, as critical mechanisms for protein regulation, are well known to enhance the functional diversity of the proteome and dramatically participate in complicated biological processes. Recent efforts in the field of cancer biology have illustrated the extensive landscape [...] Read more.
The posttranslational modifications (PTMs) of proteins, as critical mechanisms for protein regulation, are well known to enhance the functional diversity of the proteome and dramatically participate in complicated biological processes. Recent efforts in the field of cancer biology have illustrated the extensive landscape of PTMs and their crosstalk with a wide range of pro-tumorigenic signaling pathways that decisively contribute to neoplastic transformation, tumor recurrence, and resistance to oncotherapy. Cancer stemness is an emerging concept that maintains the ability of tumor cells to self-renew and differentiate and has been recognized as the root of cancer development and therapy resistance. In recent years, the PTM profile for modulating the stemness of various tumor types has been identified. This breakthrough has shed light on the underlying mechanisms by which protein PTMs maintain cancer stemness, initiate tumor relapse, and confer resistance to oncotherapies. This review focuses on the latest knowledge of protein PTMs in reprogramming the stemness of gastrointestinal (GI) cancer. A deeper understanding of abnormal PTMs in specific proteins or signaling pathways provides an opportunity to specifically target cancer stem cells and highlights the clinical relevance of PTMs as potential biomarkers and therapeutic targets for patients with GI malignancies. Full article
(This article belongs to the Special Issue New Biomarkers and Therapy for Cancer Stem Cells)
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