Special Issue "The Polymorphic World of G-Quadruplexes: From Structural Insights to Functional Activity"
Deadline for manuscript submissions: closed (30 September 2020).
Interests: Nucleic acid chemistry and structure; Nucleic acid therapeutics; Aptamers; G-quadruplex structures; Nucleosides and Nucleotides chemistry
Interests: G-quadruplex; aptamers; nucleic acid chemistry; circular dichroism; electrophoresis; NMR
Interests: G-quadruplex structures; aptamers; nucleic acid chemistry; circular dichroism; electrophoresis
G-quadruplex structures are secondary conformations of nucleic acids, whose constitutive unit is the G-tetrad or G-quartet. This building block consists of a square planar arrangement of four guanosines, in which each base is associated to the adjacent ones through four hydrogen bonds. The stacking of two or more G-tetrad units can form larger and more stable structures. The occurrance of monovalent cations, between two adjacent G-tetrads or also in the center of a G-tetrad, further contributes to the structural stability of the G-quadruplex complexes. The biological significance of these DNA or RNA structures is witnessed by their occurrence or potential formation in several regions of the human genome, such as telomeres, genes promoters, and transcription start sites. Furthermore, they can be involved in the regulation of gene expression and telomere maintenance. However, the importance of the G-quadruplex structures is not confined to genetics and molecular biological research. In fact, thanks to their remarkable stability and outstanding variability, these structures constitute the scaffolds of several DNA or RNA aptamers, with important applications in pharmaceutics, analytics, and diagnostics. Furthermore, suitable G-quadruplexes are also endowed with catalytic properties. Moreover, considering their self-assembly properties, G-quadruplexes are often exploited in building nanostructures and in developing nanodevices.
This Special Issue will concern a selection of original research, review articles, and commentaries focused on diverse topics, with particular attention on the relationship between the structural features of the G-quadruplexes and their functional role.
Dr. Aldo Galeone
Prof. Veronica Esposito
Prof. Antonella Virgilio
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- G-quadruplex thermodynamics
- G-quadruplex CD and fluorescence spectroscopy
- G-quadruplex synthesis
- G-quadruplex properties
- G-quadruplex structure
- G-quadruplex dynamics
- G-quadruplex folding
- G-quadruplex biological functions
- G-quadruplex aptamers
- G-quadruplex as a therapeutic target
- Catalytic G-quadruplexes