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The Impact of Bioactive Compounds Derived from Nature Resources on Women’s Reproductive Health

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: closed (31 March 2024) | Viewed by 2349

Special Issue Editors


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Guest Editor
Institute of Pharmaceutical Sciences, University of Graz, Graz, Austria
Interests: medical plants; functional food; antioxidant activity; anti-inflammatory properties; estrogenic/anti-estrogenic activity; cytotoxicity; phytochemical characterisation; in vitro bioavailability

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Guest Editor
Department of Pharmacy, College of Pharmacy, Pusan National University, Busan 46241, Republic of Korea
Interests: cancer; cell death; cell cycle regulation; apoptosis; autophagy; anticancer drug development; chemoprevention; breast cancer; colon cancer; gastric cancer; hepatocellular carcinoma; AOM-DSS model; bile acid; hypoxia; stem cell; differentiation; nutraceuticals; myodifferentiation; sarcopenia
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Special Issue Information

Dear Colleagues,

Beyond its physical requirements, women's reproductive health is crucial for psychological well-being that is profoundly affected by hormone level which can significantly change with age.

There are more and more women at different ages replacing conventional pharmaceutical treatments with natural, alternative ones. The bioactive components derived from nature can significantly affect woman reproductive health, contributing to the prevention and treatment of different pathophysiological processes in female reproductive system. There are several common reproductive health issues in women such as pelvic inflammatory diseases, endometriosis, uterine fibroids, polycystic ovary syndrome, female infertility, ovarian and cervical cancers and many others. On the other hand, they can lead to unwanted effects if they are used improperly or abused. This special edition will include papers related to the identification and chemical characterization of these kinds of bioactive compounds, their influence on the functioning of the female reproductive system, such as biochemical and biomolecular mechanisms of their action (effect on hormonal balance), impact on disease prevention and treatment.

Dr. Sanja Krstic
Prof. Dr. Nam Deuk Kim
Guest Editors

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Keywords

  • natural products
  • bioactive compounds
  • reproductive woman health
  • inflammatory diseases
  • ovarian cancer
  • cervical cancer
  • infertility
  • polycystic ovary syndrome

Published Papers (1 paper)

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Review

26 pages, 2287 KiB  
Review
Evidence-Based Approach for Secondary Prevention of Uterine Fibroids (The ESCAPE Approach)
by Somayeh Vafaei, Michał Ciebiera, Mervat M. Omran, Mohammad Mousaei Ghasroldasht, Qiwei Yang, Tanya Leake, Rochelle Wolfe, Mohamed Ali and Ayman Al-Hendy
Int. J. Mol. Sci. 2023, 24(21), 15972; https://doi.org/10.3390/ijms242115972 - 04 Nov 2023
Cited by 2 | Viewed by 2086
Abstract
Uterine fibroids (UFs) are common tumors in women of reproductive age. It is imperative to comprehend UFs’ associated risk factors to facilitate early detection and prevention. Simple relying on surgical/pharmacological treatment of advanced disease is not only highly expensive, but it also deprives [...] Read more.
Uterine fibroids (UFs) are common tumors in women of reproductive age. It is imperative to comprehend UFs’ associated risk factors to facilitate early detection and prevention. Simple relying on surgical/pharmacological treatment of advanced disease is not only highly expensive, but it also deprives patients of good quality of life (QOL). Unfortunately, even if the disease is discovered early, no medical intervention is traditionally initiated until the disease burden becomes high, and only then is surgical intervention performed. Furthermore, after myomectomy, the recurrence rate of UFs is extremely high with the need for additional surgeries and other interventions. This confused approach is invasive and extremely costly with an overall negative impact on women’s health. Secondary prevention is the management of early disease to slow down its progression or even halt it completely. The current approach of watchful observation for early disease is considered a major missed opportunity in the literature. The aim of this article is to present an approach named the ESCAPE (Evidence-Based Approach for Secondary Prevention) of UF management. It comprises simple, inexpensive, and safe steps that can arrest the development of UFs, promote overall reproductive health, decrease the number of unnecessary surgeries, and save billions of health care systems’ dollars worldwide. Full article
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