Special Issue "Role of Drosophila in Human Disease Research"
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 31 August 2020.
Interests: Drosophila model for human disease; epigenetics; DNA replication gene; autism spectrum disorder
Interests: Rare and Undiagnosed Diseases; Drosophila melanogaster ; Notch signaling; Dopamine Signaling
For over a century, Drosophila melanogaster has been widely used in classical and modern genetics. For over a decade, Drosophila has been used as a highly tractable animal model for studying human diseases. Many biological functions, including physical and neurological properties, are highly conserved between humans and Drosophila. Moreover, nearly 75% of human-disease-causing genes have their functional homologues in Drosophila. Drosophila has been successful in the study of various neurodegenerative diseases, metabolic syndromes, and cancer. It is also playing a role in the evaluation of candidate substances for treatment of these human diseases. Currently, scientists are studying more complex psychiatric disorders, aging, and rare intractable human genetic diseases using Drosophila models. However, we always have to keep in mind both the benefits and limitations of fly models by comparing them to other animal models, such as mouse, zebra fish, and nematode worm models. For this Special Issue, we welcome original research articles and up-to-date review articles that provide novel insights into the related academic fields.
Prof. Masamitsu Yamaguchi
Prof. Shinya Yamamoto
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
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- Drosophila melanogaster
- Human disease model
- Psychiatric disorder
- Intellectual disorder
- Metabolic syndrome
- Epigenetic dysregulation
- Mitochondrial disorder
- Infectious diseases
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Authors: Fukiko Kitani-Morii et al
Abstract: Charcot-Marie-Tooth disease (CMT) is the most frequent hereditary peripheral neuropathy in the world. Typical clinical manifestations of CMT are young-onset and slowly progressive distal dominant muscle atrophy and sensory loss. Until now, CMT has no radical treatments. Currently, more than 80 disease-causing genes have been identified and advances in genetic screening are expected to continue discovering new disease-causing genes. Drosophila model of CMT can reproduce the disease phenotype with diverse genetic backgrounds and offer many advantages for CMT research. In this review, we describe the major findings and recent advances on the molecular pathogenesis of axonal CMT and discuss future prospects for the field.
Title: Drosophila model to study the role of glia in human neuronal diseases
Authors: Im-Soon Lee
Abstract: Glial cells are key players for proper formation and maintenance of nervous system, thus contributing to neuronal health and disease in human. However, little is known about the molecular pathways that govern glia-neuron communication in the diseased brain. Drosophila provides a useful in vivo model to explore the conserved molecular details of glial cell biology and their contributions to brain function and disease susceptibility. In this review, we will address recent findings on Drosophila models that explore glial influence on normal neuronal activity and specific glial defects that cause neuronal death.
Title: Mass spectrometry imaging for metabolites imaging in Drosophila melanogaster -A review
Authors: Shuichi Shimma
Abstract: Mass spectrometry imaging (MSI) is a technology that directly detects molecules in a sample by mass spectrometry and visualizes their distribution of various molecules without labeling. Currently, it has been applied to various samples, and molecular imaging results in Drosophila melanogaster (D. melanogaster) using MSI have also been reported. Although there have been few reports on D. melanogaster analysis using MSI, it is expected that a more detailed understanding of the disease state will be possible in the future. For example, a comparison of biomolecular distributions between the disease state model and wild type would provide new insights towards the disease. In this review, the principles of MSI, its application to D. melanogaster, and its future development are described.
Title: Can we make Drosophila model of CADASIL?
Authors: Ikuko Mizuta
Title: Drosophila models of PRPS-associated disorders using CRISPR/Cas9
Authors: Keemo Delos Santos, Eunjeong Kwon, Nam-Sung Moon
Abstract: While a plethora of genetic techniques have been developed over the past century, modifying specific genomic sequences of the fruit fly has been a difficult, if not impossible, task for Drosophila geneticists. CRISPR/Cas9 truly redefined molecular genetics and provided new tools to model human diseases in Drosophila melanogaster. This is particularly true for genes whose protein sequences are highly conserved. Phosphoribosyl pyrophosphate synthetase (PRPS) is a rate-limiting enzyme in nucleotide metabolism whose missense mutations are found in a number of neurological disorders. In addition, PRPS is deregulated in cancer, particularly those that become resistant to cancer therapy. Notably, Drosophila PRPS share about 90% protein sequence identity with its human orthologs, making it an ideal gene to study via CRISPR/Cas9. In this review, we will discuss potential applications of Drosophila CRISPR/Cas9 to model PRPS-dependent disorders and other metabolic diseases that are associated with nucleotide metabolism.