Role of Cell Adhesion Molecules in Cellular Communication and Signal Transduction
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: closed (31 January 2025) | Viewed by 1328
Special Issue Editor
Interests: nervous system; cell adhesion molecules; development; synaptic function and plasticity; recovery after trauma; spinal cord injury; traumatic brain injury; neurodegenerative diseases; microglia; mitochondria
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Cell adhesion molecules not only play a role in cell recognition but are also important in the cell that responds to the recognition event. Adhesion molecules are not only expressed at the cell surface but also in the extracellular matrix, which comprises the ligands for particular cell surface receptor molecules. A rough estimate suggests that at least 1000 molecules of these kinds exist, including their splice variants, which are expressed not only in the central and peripheral nervous systems but also in organs that display similar functions, such as the immune system, kidneys and reproductive systems. Upon the initiation of recognition events, the cell responds with intracellular signaling cascades, which can evoke a broad spectrum of cascades that determine whether a ligand–receptor couple initiates certain functions, such as cell migration and survival, as well as neurite outgrowth or inhibition and synapse formation and synaptic plasticity. All of these functions are important for the development of an adult nervous system, reacting positively or negatively to its microenvironment. Signaling molecules may affect, for instance, the cytoskeleton, mitochondria and autophagosomes, as well as translation and transcription. These events are crucial to such development as they respond to environmental cues in regeneration after trauma. Mutations of adhesion molecules result in many diseases. The outcomes of mutations have been studied in humans and several animal models, including mouse and zebrafish. The elucidation of the consequences of mutations will help us to design agents to ameliorate the consequences of mutations in diseases and aging.
Prof. Dr. Melitta Schachner
Guest Editor
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Keywords
- adhesion molecule
- signal transduction
- translation
- transcription
- mitophagy
- autophagy
- synapse formation
- synaptic plasticity
- neural diseases
- aging
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