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Advanced Research on Cardiovascular Disease and Its Emerging New Biomarkers

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: closed (30 April 2022) | Viewed by 3969

Special Issue Editor


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Guest Editor
Research Team of Physiopathologie et Epidémiologie Cérébro-Cardiovasculaires (PEC2, EA 7460), Faculté des Sciences de Santé, Université de Bourgogne-Franche Comté, 21000 Dijon, France
Interests: oxidative stress; free radicals; cardioprotection; mitochondria; humanin; mRNA
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Special Issue Information

Dear Colleagues,

A biomarker is defined as “a characteristic that is objectively measured and evaluated as an indicator of normal biological processes, pathogenic processes, or pharmacologic responses to a therapeutic intervention”. Biomarkers are, by definition, quantifiable characteristics of biological processes, but to identify biomarkers requires the determination of their relevance and validity. Among the most validated biomarkers that are currently in use, inflammation-related markers are prominent. Innovative biomarkers have emerged as relevant contributors in the field of energy homeostasis, and as valid biomarkers of various cardiovascular and metabolic diseases. Among these presumed and specific biomarkers, several members of the TGF-Beta super-family, GDF15, GDF11, newly emerging cardiokines, miRNAs, and markers discovered via proteomics in relation to oxidative stress are involved in cardiovascular disease. The evaluation of their circulating levels might provide new insights into the course of the disease. Finally, innovative and specific biomarkers can also serve as new diagnostic markers for the detection of cardiovascular disorders to guide prognostication and emerging therapeutics. Authors are invited to submit original articles and review manuscripts addressing the topic of this Special Issue.

Prof. Dr. Luc Rochette
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

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Keywords

  • biomarker
  • diagnostic
  • cardiovascular diseases
  • pathophysiological pathways
  • inflammation
  • growth factors
  • cardiokines
  • miRNAs
  • proteomics
  • therapeutic

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Published Papers (1 paper)

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Review

13 pages, 792 KiB  
Review
Telomere Length: A Cardiovascular Biomarker and a Novel Therapeutic Target
by Marios Sagris, Panagiotis Theofilis, Alexios S. Antonopoulos, Konstantinos Tsioufis and Dimitris Tousoulis
Int. J. Mol. Sci. 2022, 23(24), 16010; https://doi.org/10.3390/ijms232416010 - 16 Dec 2022
Cited by 25 | Viewed by 3525
Abstract
Coronary artery disease (CAD) is a multifactorial disease with a high prevalence, particularly in developing countries. Currently, the investigation of telomeres as a potential tool for the early detection of the atherosclerotic disease seems to be a promising method. Telomeres are repetitive DNA [...] Read more.
Coronary artery disease (CAD) is a multifactorial disease with a high prevalence, particularly in developing countries. Currently, the investigation of telomeres as a potential tool for the early detection of the atherosclerotic disease seems to be a promising method. Telomeres are repetitive DNA sequences located at the extremities of chromosomes that maintain genetic stability. Telomere length (TL) has been associated with several human disorders and diseases while its attrition rate varies significantly in the population. The rate of TL shortening ranges between 20 and 50 bp and is affected by factors such as the end-replication phenomenon, oxidative stress, and other DNA-damaging agents. In this review, we delve not only into the pathophysiology of TL shortening but also into its association with cardiovascular disease and the progression of atherosclerosis. We also provide current and future treatment options based on TL and telomerase function, trying to highlight the importance of these cutting-edge developments and their clinical relevance. Full article
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