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Special Issue "Calmodulin Binding Proteins"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 31 January 2021.

Special Issue Editors

Prof. Dr. Danton O'Day
Guest Editor
Department of Biology, University of Toronto Mississauga, Mississauga, Ontario, L5L 1C6, Canada; Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario, M5S 3G5, Canada
Prof. Dr. Robert Huber
Guest Editor
Department of Biology, Trent University, Peterborough, Ontario, K9L 0G2, Canada

Special Issue Information

Dear Colleagues,

Hundreds of different proteins bind to and are regulated by the small calcium-binding protein calmodulin (CaM). These calmodulin binding proteins (CaMBPs) serve multiple, critical biomedical functions. Unlike other protein-protein interactions, binding to CaM does not involve a defined amino acid sequence. Instead, it is mediated by a diversity of canonical and non-canonical calcium-dependent binding motifs and a smaller but still variable number of calcium-independent IQ, IQ-like and other binding domains. Despite this variability, CaMBP regulation is tightly controlled and these proteins mediate diverse cellular functions as enzymes, tethers, adaptors, translocators, ion channels, and regulators of calcium signal transduction. As a result, CaMBPs are critical to a multitude of central biological processes, from inflammation to learning, and memory, as well as to a diversity of diseases including Alzheimer’s, cancers and cardiac arrythmias, to name a few. This comprehensive Special Issue “Calmodulin Binding Proteins” brings the complexity of these topics to light, serving not only as an introduction but also as a guide for future research.

Prof. Dr. Danton O'Day
Prof. Dr. Robert Huber
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • adaptor proteins
  • calcineurin
  • calmodulin binding domains
  • calmodulin-dependent kinases
  • cancer
  • ion channels
  • IQ motifs
  • neurodegeneration
  • protein targeting
  • protein translocation

Published Papers

This special issue is now open for submission.
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