Special Issue "Calmodulin Binding Proteins"
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 31 January 2021.
Hundreds of different proteins bind to and are regulated by the small calcium-binding protein calmodulin (CaM). These calmodulin binding proteins (CaMBPs) serve multiple, critical biomedical functions. Unlike other protein-protein interactions, binding to CaM does not involve a defined amino acid sequence. Instead, it is mediated by a diversity of canonical and non-canonical calcium-dependent binding motifs and a smaller but still variable number of calcium-independent IQ, IQ-like and other binding domains. Despite this variability, CaMBP regulation is tightly controlled and these proteins mediate diverse cellular functions as enzymes, tethers, adaptors, translocators, ion channels, and regulators of calcium signal transduction. As a result, CaMBPs are critical to a multitude of central biological processes, from inflammation to learning, and memory, as well as to a diversity of diseases including Alzheimer’s, cancers and cardiac arrythmias, to name a few. This comprehensive Special Issue “Calmodulin Binding Proteins” brings the complexity of these topics to light, serving not only as an introduction but also as a guide for future research.
Prof. Dr. Danton O'Day
Prof. Dr. Robert Huber
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
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- adaptor proteins
- calmodulin binding domains
- calmodulin-dependent kinases
- ion channels
- IQ motifs
- protein targeting
- protein translocation