ijms-logo

Journal Browser

Journal Browser

Thyroid Disorders and Cancers: Molecular Mechanisms and Advanced Therapies

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 30 September 2024 | Viewed by 553

Special Issue Editor


E-Mail Website
Guest Editor
Department of Medicine and Aging Sciences, University “G. d’Annunzio” of Chieti-Pescara, 66100 Chieti, Italy
Interests: endocrine-related adverse events; immune checkpoint inhibitors; thyroid autoimmunity; thyroid cancer; autoimmune diseases; hypophysitis; pituitary

Special Issue Information

Dear Colleagues,

Thyroid disorders, such as autoimmune thyroid disease, thyroid nodules, and thyroid cancer (TC), are among the most common diseases in the general population, with a higher incidence in women. The prevention of disease is an ambitious target for clinicians and scientists, but it is not always feasible, mainly due to the underlying pathogenetic mechanisms not being entirely elucidated. Thus, understanding the relevant molecular mechanisms is crucial for proposing novel therapies that can overcome the current barriers to the prevention and treatment of thyroid disorders and thyroid cancer. Furthermore, standard treatment, also known as standard of care, may not be suitable or equally effective for every patient.

The aims of this Special Issue are as follows: (a) to highlight recent advances in molecular mechanisms of thyroid disorders and their potential therapeutic implications, and (b) to suggest new treatment strategies overcoming the limitations of current approaches.

The Special Issue will include original research, review articles, short communications, case reports and/or case series addressing the specific aims and objectives outlined.

Dr. Giulia Di Dalmazi
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • autoimmune thyroid disease
  • hypothyroidism
  • residual thyroid symptoms
  • thyroid nodules
  • thyroid cancer
  • radioiodine refractory-differentiated thyroid cancer
  • drug discovery
  • novel treatments
  • standard of care

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Review

18 pages, 3229 KiB  
Review
Promising Role of Alkaloids in the Prevention and Treatment of Thyroid Cancer and Autoimmune Thyroid Disease: A Comprehensive Review of the Current Evidence
by Giulia Di Dalmazi, Cesidio Giuliani, Ines Bucci, Marco Mascitti and Giorgio Napolitano
Int. J. Mol. Sci. 2024, 25(10), 5395; https://doi.org/10.3390/ijms25105395 - 15 May 2024
Viewed by 357
Abstract
Thyroid cancer (TC) and thyroid autoimmune disorders (AITD) are among the most common diseases in the general population, with higher incidence in women. Chronic inflammation and autoimmunity play a pivotal role in carcinogenesis. Some studies, indeed, have pointed out the presence of AITD [...] Read more.
Thyroid cancer (TC) and thyroid autoimmune disorders (AITD) are among the most common diseases in the general population, with higher incidence in women. Chronic inflammation and autoimmunity play a pivotal role in carcinogenesis. Some studies, indeed, have pointed out the presence of AITD as a risk factor for TC, although this issue remains controversial. Prevention of autoimmune disease and cancer is the ultimate goal for clinicians and scientists, but it is not always feasible. Thus, new treatments, that overcome the current barriers to prevention and treatment of TC and AITD are needed. Alkaloids are secondary plant metabolites endowed with several biological activities including anticancer and immunomodulatory properties. In this perspective, alkaloids may represent a promising source of prophylactic and therapeutic agents for TC and AITD. This review encompasses the current published literature on alkaloids effects on TC and AITD, with a specific focus on the pathways involved in TC and AITD development and progression. Full article
Show Figures

Figure 1

Back to TopTop