After AlphaFold2: Exploring beyond Its Limits
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: closed (20 August 2023) | Viewed by 8529
Special Issue Editor
Interests: protein folding; foldamer; modeling; fluorescence; AlphaFold2
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
AlphaFold2(AF2) has an enormous impact on the scientific and medical fields. AF2 can predict the three-dimensional structures of proteins from their primary amino acid sequence at high accuracy. Despite the achievement of significant breakthroughs, there is still room for development. Researchers have recognized the limitations of AF2, reporting that the prediction of the effect of missense mutations on proteins and conformational changes of proteins upon binding ions (or ligands) is challenged. For example, kinases play essential roles in cellular signaling and in diseases. The accuracy of their structural information is important for drug discovery and development. However, the prediction of conformational changes of kinases by AF2, so-called open and closed conformations, need to be approached in a cautious manner.
In this Special Issue, we aim to collect new research and reviews that highlight any efforts to overcome AF2’s limitations and the next generation of algorithms. In addition, the application of AF2 in predicting membrane proteins, kinases, and intrinsically disordered proteins (IDPs), and designing de novo proteins is encouraged.
Prof. Dr. Ho-Jin Lee
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- AlphaFold2
- AF2
- kinases
- SNP
- conformational change
- membrane
- GPCR
- ion and ligand binding
- algorithm
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue policies can be found here.
