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Special Issue Information

Dear Colleagues,

This special issue aims to summarize new advances in the treatment and diagnosis of COPD with a special focus on cutting-edged diagnostic/prognosis tools, potential treatments and novel pathogenic pathways involved in disease. Advances in understanding the natural history of COPD and the development of strategies to assess COPD early in the disease is crucial to lower disease mortality. In this context, different approaches, from basic to translational research would constitute a particularly relevant opportunity to join efforts in improving our knowledge on these topics. For this reason, we invite you to submit research articles, either through original research or review formats. We especially welcome manuscripts that focus on the early diagnosis of COPD.

Dr. Amanda Iglesias
Dr. Kazufumi Nakamura
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

early COPD
diagnosis
biomarker
pathogenic pathways
new treatments

Published Papers (2 papers)

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Research

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Open AccessArticle

Mesenchymal Stem Cells from COPD Patients Are Capable of Restoring Elastase-Induced Emphysema in a Murine Experimental Model

Carlos Río

Andreas K. Jahn

Aina Martin-Medina

Alba Marina Calvo Bota

Mª Teresa De Francisco Casado

Pere Joan Pont Antona

Orlando Gigirey Castro

Ángel Francisco Carvajal

Cristina Villena Portella

Cristina Gómez Bellvert

and

Int. J. Mol. Sci. 2023, 24(6), 5813; https://doi.org/10.3390/ijms24065813 - 18 Mar 2023

Viewed by 204

Abstract

COPD is a chronic lung disease that affects millions of people, declining their lung function and impairing their life quality. Despite years of research and drug approvals, we are still not capable of halting progression or restoring normal lung function. Mesenchymal stem cells (MSC) are cells with extraordinary repair capacity, and MSC-based therapy brings future hope for COPD treatment, although the best source and route of administration are unclear. MSC from adipose tissue (AD-MSC) represents an option for autologous treatment; however, they could be less effective than donor MSC. We compared in vitro behavior of AD-MSC from COPD and non-COPD individuals by migration/proliferation assay, and tested their therapeutic potential in an elastase mouse model. In addition, we tested intravenous versus intratracheal routes, inoculating umbilical cord (UC) MSC and analyzed molecular changes by protein array. Although COPD AD-MSC have impaired migratory response to VEGF and cigarette smoke, they were as efficient as non-COPD in reducing elastase-induced lung emphysema. UC-MSC reduced lung emphysema regardless of the administration route and modified the inflammatory profile in elastase-treated mice. Our data demonstrate equal therapeutic potential of AD-MSC from COPD and non-COPD subjects in the pre-clinical model, thus supporting their autologous use in disease. Full article

(This article belongs to the Special Issue Advance in Pathogenesis, Diagnosis, and Treatment of Chronic Obstructive Pulmonary Disease (COPD))

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Review

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Open AccessReview

Applying Next-Generation Sequencing and Multi-Omics in Chronic Obstructive Pulmonary Disease

Pei Yee Tiew

Oliver W. Meldrum

and

Sanjay H. Chotirmall

Int. J. Mol. Sci. 2023, 24(3), 2955; https://doi.org/10.3390/ijms24032955 - 03 Feb 2023

Viewed by 766

Abstract

Microbiomics have significantly advanced over the last decade, driven by the widespread availability of next-generation sequencing (NGS) and multi-omic technologies. Integration of NGS and multi-omic datasets allow for a holistic assessment of endophenotypes across a range of chronic respiratory disease states, including chronic obstructive pulmonary disease (COPD). Valuable insight has been attained into the nature, function, and significance of microbial communities in disease onset, progression, prognosis, and response to treatment in COPD. Moving beyond single-biome assessment, there now exists a growing literature on functional assessment and host–microbe interaction and, in particular, their contribution to disease progression, severity, and outcome. Identifying specific microbes and/or metabolic signatures associated with COPD can open novel avenues for therapeutic intervention and prognosis-related biomarkers. Despite the promise and potential of these approaches, the large amount of data generated by such technologies can be challenging to analyze and interpret, and currently, there remains a lack of standardized methods to address this. This review outlines the current use and proposes future avenues for the application of NGS and multi-omic technologies in the endophenotyping, prognostication, and treatment of COPD. Full article

(This article belongs to the Special Issue Advance in Pathogenesis, Diagnosis, and Treatment of Chronic Obstructive Pulmonary Disease (COPD))

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