NK Cells, Immune Response in Pathology and Cancer 2.0

Dear Colleagues,

Numerous studies relate the role of different immune system biomarkers related to susceptibility, prognostic and predictive factors in several human solid and liquid tumors in humans. However, little is known about innate immune mechanisms that allow a tumor cell to escape from immune control systems.

The innate immune system is a highly dynamic system where different types of cells, ligands, and receptors are involved, including the spatial and temporal components, which are critical because they are associated with age, sex, and life habits interaction with toxics. From the clinical point of view, NK cells are essential for their role in detecting cancer. Besides, these cells present different types of receptors that allow modulating their activity. Most of these receptors tend to be highly polymorphic and tend to present high allelic variability, revealing different omic scenarios (genomic, transcriptomic, and proteomics) at the individual level, which searches for cause and effect even more difficult in individuals with tumors.

Given the enormous potential presented by NK analysis, there is a need to characterize, analyze and interpret the receptor and ligand as well as the mechanisms of action in different types of tumors, as well as to create solid and complete databases for full implementation in the clinical context, thus allowing the user to clarify the causes of carcinogenesis, metastasis, recurrence or to estimate the recurrence time, among other uses. Several studies point to a promising future for NK analysis in the different fields of clinical medical science, opening up an important new area of research.

Apart from their indisputable role in cancer, these cells and their cell receptors are also very important in the immune response to transplants, both of solid organs and hematopoietic transplants. The individual variation of the omic relationships of the NK cell could be of great help in determining the cause of heath and sickness.

More published papers could be found in the closed Special Issue: NK Cells, Immune Response in Pathology and Cancer.

Dr. Isabel Legaz Pérez
Dr. Manuel Muro
Guest Editors

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• cancer
• NK cells
• biomarkers
• innate immune system