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Nutrients
Special Issues
The Effects of Dietary Protein, Polysaccharide and Micronutrient Fortification on...
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The Effects of Dietary Protein, Polysaccharide and Micronutrient Fortification on Disease

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Proteins and Amino Acids".

Deadline for manuscript submissions: 25 May 2024 | Viewed by 1721

Special Issue Editors

Dr. Yongting Luo

E-Mail Website
Guest Editor
Department of Nutrition and Health, Beijing Advanced Innovation Center for Food Nutrition and Human Health, China Agricultural University, Beijing 100083, China
Interests: cardiovascular disease; atherosclerosis; vascular remodeling; cancer; mitochondria; cell signaling; cell metabolism
Special Issues, Collections and Topics in MDPI journals
Dr. Junjie Luo

E-Mail Website
Co-Guest Editor
Beijing Advanced Innovation Center for Food Nutrition and Human Health, Department of Nutrition and Health, China Agricultural University, Beijing 100083, China
Interests: cardiovascular disease; metabolic diseases; mitochondrial metabolism; mtDNA mutation/editing; ROS
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The observation that healthy diets are beneficial for human beings has boosted interest in the concept of “food as medicine” and “preventive treatment”. Proteins, polysaccharides, and micronutrients are versatile natural molecules that are ubiquitous in the biosphere and whose biological effects are either structure-, protection-, or storage-related. These bioactive nutrients modulate transcription factors involved in inflammation and oxidative stress, mitigate mitochondrial dysfunction, act as senolytics, and impact the epigenome by altering the metabolism. As a consequence, tailored diets fortified with proteins, polysaccharides, or micronutrients have been developed to ameliorate a wide array of diseases, such as metabolic disease, cardiovascular disease, intestinal disease, and neurodegenerative disease.

This Special Issue of Nutrients, entitled “The Effects of Dietary Protein, Polysaccharide and Micronutrient Fortification on Disease”, aims to be an interdisciplinary platform that covers all beneficial aspects related to proteins, polysaccharides, and micronutrients. We invite well-designed research articles, reviews, and meta-analysis studies addressing the development, modulation, and characterization of new dietary strategies with bioactive protein, polysaccharide, and micronutrient fortification for the treatment of various disorders and their complications.

Dr. Yongting Luo
Dr. Junjie Luo
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • polysaccharide
  • protein
  • micronutrient
  • beneficial effects
  • metabolic disease
  • cardiovascular disease
  • intestinal disease
  • neurodegenerative disease

Published Papers (1 paper)

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Research

15 pages, 5252 KiB  
Article
Dandelion Polysaccharides Ameliorate High-Fat-Diet-Induced Atherosclerosis in Mice through Antioxidant and Anti-Inflammatory Capabilities
by Shuaishuai Zhou, Zi Wang, Yanling Hao, Peng An, Junjie Luo and Yongting Luo
Nutrients 2023, 15(19), 4120; https://doi.org/10.3390/nu15194120 - 24 Sep 2023
Cited by 4 | Viewed by 1536
Abstract
Dandelion (Taraxacum officinale), a member of the Asteraceae (Compositae) family, is well known as the traditional medical plant. Dandelion polysaccharides, a natural active ingredient extracted from the dandelion, possess immune regulation, anti-inflammatory, antioxidant, and anti-aggregation properties. These properties suggest that dandelion [...] Read more.
Dandelion (Taraxacum officinale), a member of the Asteraceae (Compositae) family, is well known as the traditional medical plant. Dandelion polysaccharides, a natural active ingredient extracted from the dandelion, possess immune regulation, anti-inflammatory, antioxidant, and anti-aggregation properties. These properties suggest that dandelion polysaccharides might alleviate atherosclerosis. Using an ApoE−/− atherosclerotic mice model fed a high-fat diet, we investigated the impact and potential mechanism of dandelion polysaccharides on atherosclerosis. We observed that dandelion polysaccharides significantly reduced the levels of triglyceride, total cholesterol, and low-density lipoprotein-cholesterol in serum, while elevated the high-density lipoprotein-cholesterol level. Concomitantly, dandelion polysaccharides reduced the area of atherosclerotic lesions and necrotic core of the aortic sinus, and increased the collagen content. Mechanistic studies showed that dandelion polysaccharides were effective in reducing serum malondialdehyde levels while elevating the enzymatic activities of superoxide dismutase and glutathione peroxidase. Furthermore, dandelion polysaccharides reduced the expression of chemotactic factor Mcp-1 and pro-inflammatory cytokines (Tnf-α, Il-1β, and Il-6) in atherosclerotic lesions. Overall, these results indicated that dandelion polysaccharides may take an important part in the attenuation of atherosclerosis via its antioxidant and anti-inflammatory properties. Full article
(This article belongs to the Special Issue The Effects of Dietary Protein, Polysaccharide and Micronutrient Fortification on Disease)
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