Mitochondria in Aging and Aging-Related Diseases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: closed (20 May 2025) | Viewed by 1305
Special Issue Editor
Interests: cardiovascular disease; atherosclerosis; vascular remodeling; mitochondria; hypertension; cell signaling; mTOR; iron metabolism
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Aging is a chronic functional disarrangement and is the dominant risk factor for most human diseases. Mitochondria are a central hub of aging. Alterations in mitochondrial morphology and decline in mitochondrial function have been widely observed during aging, manifested by elevated ROS production, mitochondrial DNA (mtDNA) mutations, protein oxidation and abnormal energy metabolism, changes in mitochondrial content and mitochondrial biogenesis. As a consequence, these structural and functional defects in mitochondria impaired mitochondrial quality control, mitochondrial dynamics, and mitochondrial-to-nuclear signalling, all of which result in cellular senescence and a variety of aging-related pathophysiological characteristics. For instance, mitochondria are functionally required in high-energy demanding tissues like the heart, skeletal muscle, and brain. Therefore, aging-related mitochondrial dysfunction and subsequent abnormal cell signalling have been observed in many diseases affecting these tissues, including cardiomyopathy, atherosclerosis, hypertension, aortic aneurysm, aortic dissection, Parkinson’s disease (PD), and Alzheimer’s disease (AD). In addition, the aging-related accumulation of mtDNA mutations causes metabolic remodelling, genomic instability and inflammation, and contributes to carcinogenesis, Marfan syndrome, Werner syndrome, and ataxia telangiectasia with unclear cellular and molecular mechanisms.
Contributions to this Special Issue will further explore the fields of mitochondria in aging and aging-related diseases and provide a theoretical and molecular basis for developing new strategies for human health and treating related diseases. Well-designed research articles and reviews on these related topics, especially at the cellular and molecular levels, are welcome.
Dr. Yongting Luo
Guest Editor
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Keywords
- mitochondria
- aging
- reactive oxygen species
- antioxidants
- mitochondrial metabolism
- mitochondrial biogenesis
- mitochondrial dynamics
- mtDNA mutations
- mitophagy
- mitochondrial signalling
- inflammation
- cancer
- metabolic disease
- cardiovascular disease
- neurodegenerative disease
- life span
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