Natural Products with Anti-neuroinflammatory Activity
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".
Deadline for manuscript submissions: closed (30 December 2024) | Viewed by 593
Special Issue Editor
Interests: natural products; biological activity; structure determination; structure-activity relationships; mechanism of action; chemical synthesis of natural products
Special Issue Information
Dear Colleagues,
Chronic, excessive neuroinflammation is a key feature of neurodegenerative diseases including Alzheimer’s disease (AD) and Parkinson’s disease (PD). Microglia are the resident immune cells of the central nervous system (CNS) and subserve numerous supportive functions, contributing to diverse processes such as neurodevelopment, synaptic maintenance and remodeling, synaptic plasticity, and promotion of myelination. As an important component of microglial cells, the inflammasomes play an important role in the immune response and disease development. After exposure to certain exogenous stimuli, for example, lipopolysaccharide (LPS), the inflammatory stimulus activates the pyrin domain-containing protein 3 (NLRP3) inflammasome and the formation of the multi-protein inflammasome complex. The inflammasome complex contributes to the auto-catalysis of pro-caspase 1, generating the components of mature caspase-1. Active caspase-1 then processes the release of the pro-inflammatory cytokines IL-1β and IL-18, leading to pro-inflammatory demise of microglia. Natural products from plants and microorganisms have now become promising candidates as therapeutic agents because of their anti-inflammatory properties. Phytochemicals including flavonoids, terpenoids, alkaloids, and lignans have generated interest as inflammasome inhibitor candidates for relevant inflammatory diseases within the nervous system. Considering their natural scarcity, chemical synthesis will be highly desirable to facilitate in-depth biological mechanism research. The discovery of small-molecular inhibitors targeting NLRP3 inflammasome is an attractive therapeutic strategy for the treatment of neurodegenerative diseases.
Prof. Dr. Jin-Ming Gao
Guest Editor
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Keywords
- natural product chemistry
- natural product synthesis
- neurodegenerative diseases
- anti-neuroinflammatory
- molecular mechanism
- biological probes
- targeting inflammasomes
- NLRP3
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