Scleroderma: From Biomarkers to Therapeutic Targets
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 20 September 2025 | Viewed by 1483
Special Issue Editor
Special Issue Information
Dear Colleagues,
This special issue, “Scleroderma: From Biomarkers to Therapeutic Targets”, delves into the latest advancements in understanding the complex mechanisms underlying scleroderma (systemic sclerosis and localized scleroderma). We welcome submissions on a variety of topics, including but not limited to: Updates or new findings on serological biomarkers, such as cytokines and chemokines, pivotal in predicting disease activity and progression. Utilization of peripheral blood flow cytometry to elucidate immune cell dynamics and their role in scleroderma. Comprehensive skin histology findings and innovative staining techniques for RNA and protein expression, providing deeper insights into tissue-specific molecular alterations. Examination of the epigenetic landscape through DNA methylation studies, shedding light on regulatory mechanisms influencing gene expression. RNA sequencing of skin and blood samples from scleroderma patients and mouse models, offering a detailed transcriptomic perspective. Genetic and genomic studies that further enhance our understanding of the hereditary factors and genomic instability associated with the disease. Together, these multidisciplinary approaches will pave the way for identifying novel therapeutic targets and developing precision medicine strategies to improve patient outcomes.
Dr. Kathryn Seraphin Torok
Guest Editor
Manuscript Submission Information
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Keywords
- scleroderma
- biomarkers
- epigenetics
- RNA sequencing
- genetics and genomics
- therapeutic targets
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