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Medicinal Plants for Tumor Treatments

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Plant Sciences".

Deadline for manuscript submissions: 20 June 2025 | Viewed by 1029

Special Issue Editors


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Guest Editor
Reproduction et Développement, Université Clermont Auvergne, CNRS UMR6293, INSERM U1103, 28 Place Henri Dunant, BP38, 63001 Clermont-Ferrand, France
Interests: nuclear receptors; prostate; reproduction; lipids; steroids; endocrinology; cancer; ligand screening; mouse models
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Equipe 5, Neurobiologie des Comportements Alimentaires/Neurobiology of Feeding Behaviours 9E, Boulevard Jeanne d'Arc, 21000 Dijon, France
Interests: oxysterols; very-long-chain fatty acids; lipid metabolism; diet; peroxisomes; biotherapies; inflammation; cancer; cell cycle and apoptosis; autophagy; biological membranes; oxidative damage; biomarkers; neurodegenerative diseases
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

For decades, the majority of cancer cases have been considered Western-country diseases. Indeed, except for tumors with a viral origin, the vast majority of tumors develop with age, and the developing countries did not have a life expectancy that favored the development of cancer. Moreover, the majority of treatments were derived from extremely expensive pharmaceutical industry work. With the increasing incidence of cancer in countries with low GNP, treatments used in Western countries are not accessible to the general population. These countries have been able to keep their links with ethnobotany and traditional practitioners intact. On the other hand, Western patients are reluctant to use “modern” medicine, as shown by the COVID-19 crisis and the suspicion regarding RNA vaccines. A return to chemistry closer to what they know would allow for better acceptance.

Altogether, the interest in plant-derived compounds that could be used in cancer treatment has been increasing for several reasons: (i) using already-tested plant extracts for a different disease to treat cancer, which allows a cheaper medication; (ii) discovering new active molecules that could eventually be chemically modified to increase their efficiency; and (iii) deciphering novel signaling pathways and/or metabolism that could be targeted.

This Special Issue plans to provide new insights on the three points listed above. Hence, original research articles and reviews are welcome. Research areas may include (but are not limited to) the effects of plant extracts on various tumors, the molecular characterization of extract effects, and the chemical purification and/or modification of natural extracts.

Prof. Dr. Jean-Marc A. Lobaccaro
Dr. Anne Vejux
Guest Editors

Manuscript Submission Information

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Keywords

  • oncology
  • plant extracts
  • ethnobotany
  • tumor treatment
  • molecular characterization
  • chemical purification
  • pharmacology

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Published Papers (1 paper)

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Research

37 pages, 14167 KiB  
Article
Evaluating the Antitumor Potential of Cannabichromene, Cannabigerol, and Related Compounds from Cannabis sativa and Piper nigrum Against Malignant Glioma: An In Silico to In Vitro Approach
by Andrés David Turizo Smith, Nicolás Montoya Moreno, Josefa Antonia Rodríguez-García, Juan Camilo Marín-Loaiza and Gonzalo Arboleda Bustos
Int. J. Mol. Sci. 2025, 26(12), 5688; https://doi.org/10.3390/ijms26125688 - 13 Jun 2025
Viewed by 325
Abstract
Malignant gliomas, including glioblastoma multiforme (GBM), are highly aggressive brain tumors with a poor prognosis and limited treatment options. This study investigates the antitumor potential of bioactive compounds derived from Cannabis sativa and Piper nigrum using molecular docking, cell viability assays, and transcriptomic [...] Read more.
Malignant gliomas, including glioblastoma multiforme (GBM), are highly aggressive brain tumors with a poor prognosis and limited treatment options. This study investigates the antitumor potential of bioactive compounds derived from Cannabis sativa and Piper nigrum using molecular docking, cell viability assays, and transcriptomic and expression analyses from public databases in humans and cell lines. Cannabichromene (CBC), cannabigerol (CBG), cannabidiol (CBD), and Piper nigrum derivates exhibited strong binding affinities relative to glioblastoma-associated targets GPR55 and PINK1. In vitro analyses demonstrated their cytotoxic effects on glioblastoma cell lines (U87MG, T98G, and CCF-STTG1), as well as on neuroblastoma (SH-SY5Y) and oligodendroglial (MO3.13) cell lines, revealing interactions among these compounds. The differential expression of GPR55 and PINK1 in tumor versus normal tissues further supports their potential as biomarkers and therapeutic targets. These findings provide a basis for the development of novel therapies and suggest unexplored molecular pathways for the treatment of malignant glioma. Full article
(This article belongs to the Special Issue Medicinal Plants for Tumor Treatments)
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