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Recent Advances in Laser and Photodynamic Therapy

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 30 October 2025 | Viewed by 555

Special Issue Editors


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Guest Editor
Department of Periodontal Diseases and Oral Mucosa Diseases, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Pl. Traugutta 2, 41-800 Zabrze, Poland
Interests: oral mucosa diseases; periodontal diseases and therapy; oral potentially malignant disorders (OPMDs); PDT in dentistry; oral surgery; chronic mucosal diseases; otorhinolaryngology; inflammatory diseases of the oral cavity; tissue regeneration and wound healing; laser and light-based therapies in oral medicine
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Guest Editor
Department of Internal Diseases, Angiology and Physical Medicine, Centre for Laser Diagnostics and Therapy, Medical University of Silesia in Katowice, Batorego 15, 41-902 Bytom, Poland
Interests: cell culture; fluorescence; diagnosis; Photochemistry; photodynamic therapy (pdt); photobiology

Special Issue Information

Dear Colleagues,

We are delighted to announce a Special Issue of the International Journal of Molecular Sciences (ISSN 1422-0067), titled Recent Advances in Laser and Photodynamic Therapy”. This Special Issue aims to highlight comprehensive research articles, reviews, and communications that explore the latest developments in laser-based treatments and photodynamic therapy across various medical and scientific disciplines. We invite submissions focusing on novel photosensitizing agents, cutting-edge imaging modalities, optimized drug delivery mechanisms, and innovative clinical applications that emphasize the rapidly evolving landscape of photomedicine.

Laser and photodynamic therapies have demonstrated significant promise in the detection and treatment of diverse diseases, ranging from oncology and dermatology to infectious diseases. In recent years, advances in molecular biology, nanotechnology, and biomedical imaging have brought these fields to new levels of precision and efficacy, resulting in improved patient outcomes. Moreover, emerging techniques—such as combination therapies integrating lasers and photodynamic therapy with other modalities—are broadening the scope of applications and transforming the standard of care.

This Special Issue will serve as a multidisciplinary platform to present experimental and clinical findings on innovative methodologies, safety considerations, mechanism-based insights, and future directions. Submissions addressing novel synthetic approaches to photosensitizers, targeted drug delivery strategies, innovative in vivo or in vitro imaging protocols, and translational research are particularly welcome.

We would also like to acknowledge the indispensable contribution of Jakub Fiegler-Rudol, a student whose efforts in the preparation of editorial materials and support in the thematic development of this Special Issue are greatly appreciated.

We look forward to receiving your own valuable contributions. We are confident that this Special Issue will foster collaboration and advance knowledge in the evolving field of laser and photodynamic therapy.

Dr. Rafał Wiench
Prof. Dr. Aleksandra Kawczyk-Krupka
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • laser therapy
  • photodynamic therapy
  • photosensitizers
  • drug delivery
  • biomedical imaging
  • nanotechnology
  • combination therapies
  • translational research

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Published Papers (1 paper)

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Research

16 pages, 2347 KiB  
Article
In Vitro Evaluation of Candida spp. and Staphylococcus aureus Sensitivity to 450 nm Diode Laser-Mediated Antimicrobial Photodynamic Therapy with Curcumin and Riboflavin
by Marcin Tkaczyk, Anna Mertas, Anna Kuśka-Kiełbratowska, Jakub Fiegler-Rudol, Elżbieta Bobela, Maria Cisowska, Tadeusz Morawiec, Dariusz Skaba and Rafał Wiench
Int. J. Mol. Sci. 2025, 26(12), 5645; https://doi.org/10.3390/ijms26125645 - 12 Jun 2025
Viewed by 466
Abstract
Oral candidiasis, commonly caused by Candida (C.) albicans and other non-albicans Candida species, increases resistance to conventional antifungal therapies. This study aimed to evaluate the in vitro efficacy of antimicrobial photodynamic therapy (aPDT) using a 450 nm diode laser in combination [...] Read more.
Oral candidiasis, commonly caused by Candida (C.) albicans and other non-albicans Candida species, increases resistance to conventional antifungal therapies. This study aimed to evaluate the in vitro efficacy of antimicrobial photodynamic therapy (aPDT) using a 450 nm diode laser in combination with curcumin and riboflavin against Candida spp. and Staphylococcus (S.) aureus. Reference strains of C. albicans, C. glabrata, C. krusei, and S. aureus were exposed to aPDT under varying incubation times and laser parameters, then viable microorganism cells (CFU) counts were assessed the microbial reduction, and statistical analyses were performed to evaluate significance. aPDT significantly reduced microbial viability in a time- and dose-dependent manner. Optimal incubation times were 20 min for Candida spp. and 10 min for S. aureus, with the highest efficacy observed at 400 mW and 120 s irradiation. The photosensitizer or laser alone had no significant antimicrobial effect. Curcumin/riboflavin-mediated aPDT is a promising alternative or adjunctive approach to conventional antimicrobial therapy, particularly for resistant oral infections. Full article
(This article belongs to the Special Issue Recent Advances in Laser and Photodynamic Therapy)
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