Unraveling Immunometabolism in Sepsis: From Cellular Reprogramming to Therapeutic Targets

Dear Colleagues,

Sepsis continues to pose a major clinical and scientific challenge worldwide, driven by a complex interplay between dysregulated immune responses and profound metabolic disturbances. In recent years, immunometabolism has emerged as a crucial lens through which to reinterpret the pathophysiology of sepsis. Cellular metabolic reprogramming influences leukocyte activation, cytokine production, pathogen clearance, and ultimately the trajectory of organ dysfunction. Understanding these intricate bioenergetic shifts not only deepens our insight into disease mechanisms but also reveals a spectrum of novel biomarkers and actionable therapeutic targets.

This Special Issue, “Unraveling Immunometabolism in Sepsis: From Cellular Reprogramming to Therapeutic Targets”, aims to gather cutting-edge research and authoritative reviews that explore the metabolic underpinnings of immune dysregulation in sepsis. We encourage contributions investigating molecular pathways, translational approaches, diagnostic innovations, and experimental or clinical interventions that harness immunometabolic modulation. By bringing together expertise from immunology, metabolism, critical care, and systems biology, we hope to foster a multidisciplinary dialog that advances both scientific understanding and clinical impact. Researchers are warmly invited to submit their latest findings to help shape a more precise and therapeutically informed vision of sepsis care.

Dr. Marcello Candelli
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.