Apoptosis in Cancer Cells and New Targets for Cancer Therapy

Dear Colleagues,

Apoptosis is an orderly cellular process that occurs under physiological and pathological conditions. Understanding the underlying mechanism of this process is critical for the treatment and prevention of diseases. Excessive apoptosis may lead to diseases that are difficult to cure, such as degenerative diseases, while insufficient apoptosis, such as cancer cell occurrence, results in a loss of balance between cellular renewal and death. The mechanism of apoptosis is overly complex, involving multiple signaling pathways. The occurrence of any one of these defects will not only cause the malignant transformation of cells but also suggest new therapeutic targets in the treatment of diseases. Targeted apoptosis in cancer cells has been proved to be feasible in many studies. Additionally, many anticancer drugs have been researched with the aim of increasing the selective ability of cell death in cancer.

This Special Issue aims to extend our knowledge of the underlying molecular mechanisms of apoptosis, how apoptosis leads to carcinogenesis and how apoptosis can be used as a tool for targeted cancer therapy. Methodological studies focusing on new models and research techniques used to study these aspects are also welcome.

Prof. Dr. Taeg Kyu Kwon
Guest Editor

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• cancer cells
• apoptosis
• targeted cancer therapy
• carcinogenesis
• drug development