Molecular Research and Targeted Therapy of Lung Cancer
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (28 February 2025) | Viewed by 150
Special Issue Editor
Interests: cancer; advanced imaging techniques; lung cancer
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The landscape of lung cancer treatment is undergoing a significant change, driven by advances in molecular research and the development of targeted therapies. This special issue, titled "Molecular Research and Targeted Therapy of Lung Cancer," aims to highlight the latest discoveries in genetic mutations, novel targeted agents that are changing clinical practice, and analyses recent regulatory approvals. Indeed, understanding the genetic underpinnings of lung cancer has revealed a spectrum of significant mutations, some of which may be rare but are critical in personalizing treatment. This issue will delve especially into rarer oncogenic mutations, such as those in the ALK, ROS1, and RET genes, and their implications for patient prognosis and therapy.
Novel targeted agents, designed to specifically inhibit oncogenic drivers, have demonstrated remarkable efficacy in clinical trials. However, despite initial success, resistance to TKIs inevitably develops. Understanding the mechanisms behind this resistance is crucial for developing next-generation inhibitors. This issue aim to explore various resistance mechanisms, including secondary mutations, activation of alternative signaling pathways, and histological transformation.
Recent regulatory approvals have further expanded the arsenal of treatments available to oncologists. This issue aim to review the latest approved targeted therapies, examining their clinical trial data, mechanisms of action, and impact on current treatment guidelines.
Through this special issue, we seek to foster a deeper understanding of the molecular complexities of lung cancer and highlight the innovations that are driving progress in targeted therapy.
Dr. Morena Fasano
Guest Editor
Manuscript Submission Information
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Keywords
- lung cancer
- molecular research
- targeted therapy
- genetic mutations
- novel targeted agents
- tyrosine kinase inhibitors
- resistance mechanisms
- regulatory approvals
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