Studying Multi-Target Drug Approaches and Posttranslational Modification (PTM) Therapies

Dear Colleagues,

Multi-target therapy is the favoured pathway for achieving desired treatment effects in cancer and nervous system, cardiovascular system, and immune system diseases. Network analysis tools and computational prediction approaches have been incorporated into research of the basic mechanisms of these diseases. These computational approaches are novel, and are closely associated with the identification of the subcellular localization of so-called “multi-label” proteins. Recently, user-friendly web-server predictors have been established, whereby users can easily attain their desired results for multi-label proteins in eukaryotic, human, animal, plant, Gram-positive, and Gram-negative organisms, respectively. Posttranslational modifications (PTMs) are related to a number of diseases. In order to obtain targets’ 3D structures for rational drug design in a timely and accurate manner, both theoretical and experimental approaches of structural biology are used. Certain intermolecular and intramolecular interactions related to the migration and invasion of tumor cells may occur during the PTM process. In this Special Issue, recent advances in studying multi-target therapies and PTM will be collected. These studies may provide new perspectives on drug research and development related to tumor-targeted enzymes.

This Special Issue is supervised by Prof. Dr. Guo-Ping Zhou and assisted by our Guest Editor’ assistant editor Dr. Bo Lu, Lubo45@126.com (Institute of Biological Science and Technology, Guangxi Academy of Sciences).

Prof. Dr. Guo-Ping Zhou
Guest Editor

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