Molecular Pathogenesis of Depression and Therapeutic Mechanisms of Antidepressant Effects

Dear Colleagues,

Since the serendipitous discovery of drugs with antidepressant efficacy, monoamine-based antidepressants found widespread application. However, as new theories about the pathological process of depression have emerged, novel treatments with different mechanisms from those of existing antidepressants have become possible. This Special Issue, entitled “Molecular Pathogenesis of Depression and Therapeutic Mechanisms of Antidepressant Effects”, aims to organize new theories about the pathogenesis of depression and to suggest new therapeutic approaches to using these processes.

This Special Issue focuses on both basic science and translational research as well as clinical evidence to understand the complex nature and have a more complete comprehension of the pathophysiology of depression. Since IJMS is a journal of molecular science, pure clinical studies will not suitable for our journal. However, clinical or pure model submissions with biomolecular experiments are welcomed.

Prof. Dr. Sungho Maeng
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• depression
• antidepressants
• pathophysiology
• monoamine, glutamatergic synapse
• default mode network
• stress
• natural compounds