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Bioactive Compounds and Proteins/Peptides, Biosynthesis, and Applications

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: closed (15 August 2023) | Viewed by 12564

Special Issue Editors

Department of Biology, Division of Botany, Faculty of Science, University of Zagreb, Marulićev trg 9a, 10000 Zagreb, Croatia
Interests: phytochemistry; plant specialized metabolites; plant extract bioactivity; biotic stress; abiotic stress
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Maintaining health is one of the most important aspects of human life. Due to our very fast-paced lives, it is necessary to take in a well-balanced and nutritious diet and to reduce stress. Given that bioactive compounds and proteins/peptides from food may have beneficial effects on our organism, at least as free radical scavengers and antioxidants, they can contribute to our health. Bioactive compounds and proteins/peptides from food can be an asset, since their actions in the body may have beneficial effects for our health. Bioactive compounds and proteins/peptides include those from nature and those that are chemically synthesised. Plants, algae or naturally occurring sources of proteins and nutrients, etc., can be efficiently used as sources of bioactive compounds and proteins/peptides. Nevertheless, the mechanisms underlying antioxidant potency in bioactive compounds and proteins/peptides are still not completely elucidated. Therefore, it is important to further develop, discuss and overview different analytical methods and methodologies in defining mechanisms underlying antioxidant potency in bioactive compounds and proteins/peptides, obtaining natural and synthesised bioactive compounds and proteins/peptides. The main focus is on the processes of analysis of mechanisms underlying antioxidant potency in bioactive compounds and proteins/peptides, as well as on processes to obtain bioactive compounds and proteins/peptides. Therefore, this Special Issue is inviting research papers on bioactive compound extraction, synthesis, implementation into food products and analysis of their bioactivity. Further, papers focused on improving the extraction, synthesis and production processes for the most efficient exploitation of bioactive compounds and proteins/peptides from plants, algae and other naturally occurring sources of bioactive compounds and proteins/peptides are welcome.

This Special Issue invites review and original research papers dealing with:

  • Extraction of bioactive compounds and proteins/peptides from plants and animal-based sources (by means of nonthermal and advanced thermal techniques)
  • Analytical methods in determining the biological potential in bioactive compounds and proteins/peptides (determination of antiproliferative and cytotoxic activity)
  • In silico analysis and optimisation of production of bioactive proteins and peptides
  • Comparison and critical overview of the most important tests used to determine the antioxidant activity, methods of detection of bioactive compounds and proteins/peptides, applicability, advantages and disadvantages of these methods
  • Chemical synthesis of potent bioactive compounds and proteins/peptides
  • Potential application in design of food products (novel foods)
  • Usage of sustainable and innovative methods in obtaining bioactive compounds and proteins/peptides.

Prof. Dr. Anet Režek Jambrak
Dr. Ivana Sola
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biological potency
  • bioactive compounds and proteins/peptides
  • analytical methodology
  • food physics
  • sustainable processing
  • novel foods
  • phytochemistry

Published Papers (2 papers)

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Research

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17 pages, 5346 KiB  
Article
Isolation and Identification of Lipid-Lowering Peptides from Sacha Inchi Meal
by Kai Wang, Xiaofei Liu and Xuewu Zhang
Int. J. Mol. Sci. 2023, 24(2), 1529; https://doi.org/10.3390/ijms24021529 - 12 Jan 2023
Cited by 3 | Viewed by 1805
Abstract
Sacha inchi meal (SIM) is a by-product of sacha inchi (considered as a “super-food”) processing. In previous studies, we found that SIM protein hydrolysates exhibited pancreatic lipase inhibition activity. In this study, 10 bioactive peptides from those hydrolysates were identified. The top five [...] Read more.
Sacha inchi meal (SIM) is a by-product of sacha inchi (considered as a “super-food”) processing. In previous studies, we found that SIM protein hydrolysates exhibited pancreatic lipase inhibition activity. In this study, 10 bioactive peptides from those hydrolysates were identified. The top five peptides (NLYYKVV (NV-7), WWYVK (WK-5), WLLMWPYK (WK-8), EGLLMWPY (EY-8), and FPFFGYVWK (FK-9)) with strong pancreatic lipase inhibition activity had IC50 values of 34.01–246.50 µM, and displayed various inhibition types (mixed, non-competitive, and competitive type) by enzyme inhibition kinetics analysis. Fluorescence quenching analysis demonstrated that the interaction between the peptides and pancreatic lipase was mainly hydrogen bond and van der Waals force. The key residues involved in the peptide–enzyme interaction were determined by molecular docking. Moreover, the top two peptides were found to significantly inhibit fat accumulation and regulate lipid metabolism by alleviating the level of reactive oxygen species in HepG2 cells. Collectively, sacha inchi meal-derived peptides displayed potent lipid-lowering activity and could be used as materials of functional food. Full article
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Review

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14 pages, 2225 KiB  
Review
The Management of Diabetes Mellitus Using Medicinal Plants and Vitamins
by Clement G. Yedjou, Jameka Grigsby, Ariane Mbemi, Daryllynn Nelson, Bryan Mildort, Lekan Latinwo and Paul B. Tchounwou
Int. J. Mol. Sci. 2023, 24(10), 9085; https://doi.org/10.3390/ijms24109085 - 22 May 2023
Cited by 18 | Viewed by 10042
Abstract
Diabetes mellitus (DM) is a serious chronic metabolic disease that is associated with hyperglycemia and several complications including cardiovascular disease and chronic kidney disease. DM is caused by high levels of blood sugar in the body associated with the disruption of insulin metabolism [...] Read more.
Diabetes mellitus (DM) is a serious chronic metabolic disease that is associated with hyperglycemia and several complications including cardiovascular disease and chronic kidney disease. DM is caused by high levels of blood sugar in the body associated with the disruption of insulin metabolism and homeostasis. Over time, DM can induce life-threatening health problems such as blindness, heart disease, kidney damage, and stroke. Although the cure of DM has improved over the past decades, its morbidity and mortality rates remain high. Hence, new therapeutic strategies are needed to overcome the burden of this disease. One such prevention and treatment strategy that is easily accessible to diabetic patients at low cost is the use of medicinal plants, vitamins, and essential elements. The research objective of this review article is to study DM and explore its treatment modalities based on medicinal plants and vitamins. To achieve our objective, we searched scientific databases of ongoing trials in PubMed Central, Medline databases, and Google Scholar websites. We also searched databases on World Health Organization International Clinical Trials Registry Platform to collect relevant papers. Results of numerous scientific investigations revealed that phytochemicals present in medicinal plants (Allium sativum, Momordica charantia, Hibiscus sabdariffa L., and Zingiber officinale) possess anti-hypoglycemic activities and show promise for the prevention and/or control of DM. Results also revealed that intake of vitamins C, D, E, or their combination improves the health of diabetes patients by reducing blood glucose, inflammation, lipid peroxidation, and blood pressure levels. However, very limited studies have addressed the health benefits of medicinal plants and vitamins as chemo-therapeutic/preventive agents for the management of DM. This review paper aims at addressing this knowledge gap by studying DM and highlighting the biomedical significance of the most potent medicinal plants and vitamins with hypoglycemic properties that show a great potential to prevent and/or treat DM. Full article
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