Insights into Chronic Liver Disease and Hepatocellular Carcinoma

Dear Colleagues,

Chronic liver diseases, spanning a spectrum from metabolic disorders to viral hepatitis, have become a significant global health challenge, impacting millions of individuals worldwide. Hepatocellular carcinoma (HCC), a major consequence of chronic liver diseases, stands as a leading cause of cancer-related morbidity and mortality. The rising prevalence of these conditions underscores the critical need for publishing advanced insights to inform diagnostic, prognostic, and therapeutic strategies.

Key Themes and Research Topics:

• Diagnostic Biomarkers for Early Detection: Uncover novel diagnostic biomarkers crucial for the early identification of chronic liver diseases, specifically aiming to pinpoint individuals at heightened risk for HCC.
• Genetic and Epigenetic Profiling: Investigate genetic and epigenetic factors influencing susceptibility, progression, and response to treatment in chronic liver diseases and hepatocellular carcinoma.
• Metabolic Reprogramming in Hepatic Diseases: Explore the metabolic alterations in liver cells contributing to the development and progression of hepatocellular carcinoma.
• Microenvironmental Influences in Liver Cancer: Examine the intricate interplay between the tumor microenvironment and the initiation and advancement of hepatocellular carcinoma.
• Immunomodulation in Chronic Liver Conditions: Explore the dynamics of mucosal immunology within the liver and its impact on chronic liver diseases, including autoimmune liver disease and viral hepatitis.

This special issue, supervised by Dr. Marios Papadakis and assisted by our Topical Advisory Panel Member Dr. Stavros P. Papadakos (National and Kapodistrian University of Athens, Greece), aims to significantly contribute to our understanding of liver-related health challenges. By fostering research on these key themes, this Special Issue aspires to enhance global efforts in the diagnosis, treatment, and prevention of chronic liver diseases and HCC.

Dr. Marios Papadakis
Guest Editor

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• chronic liver disease
• hepatocellular carcinoma
• tumor microenvironment
• viral hepatitis