Epigenetic Modifiers (miRNA, lncRNA and Methylation) in Cancers

Dear Colleagues,

Extensive alterations of the epigenetic landscape are considered a hallmark of cancer, and the field of epigenetics in cancer has rapidly evolved, showing large-scale reprogramming of the epigenetic machinery function in cancer cells, involving DNA methylation, histone modifications, dynamic assembly of chromatin remodeling complexes, nucleosome positioning, and non-coding RNAs expression. In recent years, the application of next-generation sequencing (NGS) technology has enabled researchers to identify the epigenetic asset of cancer cells in association with mutations in genes controlling the epigenome, revealing new pathways relevant to cancer phenotype. Given the reversible nature of epigenetic aberrations, treatments targeting epigenetics have become an attractive strategy in cancer therapy. Different epigenetic modifiers are currently used as anticancer drugs, and recently, microRNAs and noncoding RNAs have attained significant importance in carcinogenesis as promising therapeutic targets and/or putative biomarkers.

The aim of this Special Issue is to assemble the most relevant works aimed at deciphering the molecular basis of cancer epigenetics, focusing on the role of epigenetic modifiers in the context of cancer development and progression, cancer therapy, cancer epigenome and epitranscriptome.

Original research articles or reviews will represent an important contribution to improve the present knowledge in the field.

Dr. Valentina Salsi
Guest Editor

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