Biomaterials for Bone Tissue Engineering 4.0
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Materials Science".
Deadline for manuscript submissions: 20 February 2025 | Viewed by 9812
Special Issue Editors
Interests: bone substitutes; collagen-based biomaterials for soft and hard tissue regeneration; foreign body response to biomaterials; inflammation; macrophages; multinucleated giant cells, degradation processes of biomaterials; phagocytosis; vascularization; histology; immunohistochemistry; histomorphometry
Special Issues, Collections and Topics in MDPI journals
Interests: bone
Interests: magnesium; surfaces; coating technologies; biomaterials
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The worldwide clinical demand for bone regeneration is a problematic issue in orthopaedic and maxillofacial surgery. The application of autologous bone is still the standard in bone transplantation. Due to the limited quantity of bone available for harvest and the poor quality of bone transplants—especially in elderly patients, due to bone diseases such as osteoporosis—surgeons are looking for alternatives such as bone substitute materials. The ideal grafting material enables the regeneration of bony defects up to the condition of a restitutio ad integrum, and should combine the basic mechanism of fracture healing, namely osteogenesis, osteoinduction and osteoconduction. In the last few decades, a variety of bone substitute materials with different physicochemical properties have been developed and analysed to optimize the process of bone regeneration. Furthermore, various different growth factors, cytokines and antibiotics have been incorporated into bone substitutes and matrices as so-called “composite bone grafts” in order to enhance bone healing. Moreover, different tissue engineering strategies, such as combinations with extracellular matrix proteins and/or different cell types (e.g., osteoblasts, mesenchymal stem cells or endothelial cells) have been developed with the aim of improving the regenerative properties of bone substitute materials. However, no alternative to autologous bone has been found; thus, there is a need for ongoing research to develop a composite bone graft that combines osteogenesis with inductive and conductive properties. In this context, preclinical in vitro and in vivo studies, as well as clinical trials analysing fundamental molecular processes, are crucial to define the regeneration mechanisms of new materials and tissue engineering concepts.
This Special Issue focuses on the various aspects of interactions of bone substitutes with cells and tissues. Thus, we invite contributions of reviews and original papers reporting new results in the field of bone substitute development and bone tissue engineering concepts, including in vitro and in vivo analyses as well as clinical studies, with a focus on new molecular insights.
Dr. Mike Barbeck
Prof. Dr. Reinhard Schnettler
Dr. Ole Jung
Guest Editors
Manuscript Submission Information
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Keywords
- bone tissue regeneration
- bone substitute
- bone tissue engineering
- tissue reactions
- biomaterial
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Related Special Issues
- Biomaterials for Bone Tissue Engineering in International Journal of Molecular Sciences (15 articles)
- Biomaterials for Bone Tissue Engineering 2.0 in International Journal of Molecular Sciences (13 articles)
- Biomaterials for Bone Tissue Engineering 3.0 in International Journal of Molecular Sciences (14 articles)