Special Issue "Biomaterials for Bone Tissue Engineering"
Deadline for manuscript submissions: closed (20 October 2018).
Interests: bioceramics; bone regeneration; calcium phosphate; drug delivery matrices; biomimetic ceramics; tissue engineering; biological interactions of calcium phosphates; osteoinduction
Interests: tissue engineering; cell–material interactions; cell–cell interactions; cell interactions/crosstalk; drug delivery bone substitutes; ossoinduction; osseoconduction; osteogenesis
Interests: bone substitutes; collagen-based biomaterials for soft and hard tissue regeneration; foreign body response to biomaterials; inflammation; degradation processes of biomaterials; phagocytosis; vascularization; histology; immunohistochemistry; histomorphometry
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Interests: biomaterials; bioactivity; biocompatibility; osteoclasts; foreign body giant cells; mesenchymal stromal cells; cell culture; cell differentiation; cell communication
The worldwide clinical demand for bone regeneration is a problematic issue in orthopaedic and maxillofacial surgery. The application of autologous bone is still the standard in bone transplantation. Due to the limited quantity of bone available for harvest and the poor quality of bone transplants, especially in elderly patients due to bone diseases such as osteoporosis, surgeons are looking for alternatives such as bone substitute materials. The ideal grafting material enables the regeneration of bony defects up to the condition of a restitutio ad integrum and should combine the basic mechanism of fracture healing, namely osteogenesis, osteoinduction and osteoconduction. In the last few decades, a variety of bone substitute materials with different physicochemical properties have been developed and analysed to optimize the process of bone regeneration. Furthermore, various different growth factors, cytokines and antibiotics have been incorporated into bone substitutes and matrices as so-called “composite bone grafts” in order to enhance bone healing. Moreover, different tissue engineering strategies, such as combinations with extracellular matrix proteins and/or different cell types (e.g., osteoblasts, mesenchymal stem cells or endothelial cells) have been developed with the aim of improving the regenerative properties of bone substitute materials. However, no alternative to autologous bone has been found, thus there is a need for ongoing research to develop a composite bone graft that combines osteogenesis with inductive and conductive properties. In this context, preclinical in vitro and in vivo studies, as well as clinical trials analysing fundamental molecular processes are crucial to define the regeneration mechanisms of new materials und tissue engineering concepts.
This Special Issue focuses on the various aspects of interactions of bone substitutes with cells and tissues. Thus, we invite to contributions of reviews and/or original papers reporting new results in the field of bone substitute development and bone tissue engineering concepts, including in vitro and in vivo analyses, as well as clinical studies, with a focus on new molecular insights.
Prof. Maria-Pau Ginebra
Prof. Reinhard Schnettler
Dr. Mike Barbeck
Prof. Sabine Wenisch
Manuscript Submission Information
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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- bone tissue regeneration
- bone substitute
- bone tissue engineering
- tissue reactions