Research Progress on the Mechanism and Treatment of Cardiomyopathy: Second Edition
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 31 May 2025 | Viewed by 869
Special Issue Editor
Interests: inherited cardiomyopathies; heart failure; cardiac hypertrophy; gene expression; genetics; molecular biology; single cell transcriptomics; spatial transcriptomics; proteomics; metabolomics
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Heart failure is a growing public health problem worldwide that is usually attributable to alterations in cardiac muscle function due to cardiomyopathic processes. Cardiomyopathies have diverse origins, being inherited via gene dysfunction or acquired due to various systemic disorders that manifest in heart dysfunction. Consequently, the pathogenic and molecular mechanisms that promote cardiomyopathic dysfunction are diverse and extensive. Myocardial ischemia resulting from atherosclerotic disease is by far the most frequent cause of myocardial dysfunction, but metabolic, infectious, and inflammatory disorders are also known to result in cardiomyopathy. Alterations in transcription, signaling, mitochondrial function, metabolism, cellular architecture, immune cell function, autophagy, chaperone function and other processes have been implicated at the cellular and molecular levels. Strategies to treat cardiomyopathies range from treating the underlying causes to identifying general strategies for improving systolic and diastolic function. Understanding the mechanisms behind and treatments for various cardiomyopathies will provide wide-ranging insights into the mechanisms of cardiovascular homeostasis and provide opportunities for novel and improved therapeutic targeting.
Prof. Dr. Michael T. Chin
Guest Editor
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Keywords
- cardiomyopathy
- heart failure
- cardiac hypertrophy
- dilated cardiomyopathy
- restrictive cardiomyopathy
- hypertrophic cardiomyopathy
- ischemic cardiomyopathy
- viral cardiomyopathy
- inherited cardiomyopathy
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