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Hormone/Receptor System in Human Diseases
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Hormone/Receptor System in Human Diseases

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pharmacology".

Deadline for manuscript submissions: 20 May 2025 | Viewed by 3565

Special Issue Editor

Dr. Elena Zocchi

E-Mail Website
Guest Editor
Department of Experimental Medicine, Section of Biochemistry, University of Genoa, Viale Benedetto XV 1, 16132 Genova, Italy
Interests: hormones; mechanisms of hormone action; structure, subunits and complexes of receptors; receptor function, expression and regulation; hormone/receptor signaling; interactions between receptors and hormones

Special Issue Information

Dear Colleagues,

The international, peer-reviewed, open access Special Issue titled “Hormone/Receptor System in Human Diseases” focuses on presenting innovative research discoveries, reviews, and communications, encompassing various facets of hormones, receptor characteristics and functions, molecular biology, genetics, signaling mechanisms, and their biochemical attributes in relation to human diseases. We accept Research Articles, Reviews, and Communications. The primary objective is to encourage scientists to meticulously document their experimental and theoretical findings. To facilitate reproducibility, comprehensive experimental details must be provided, and supplementary electronic material will be utilized by the journal as needed.

This Special Issue is supervised by Prof. Elena Zocchi and assisted by our Assistant Editor, Dr. Sonia Spinelli, soniaspinelli@gaslini.org, (Laboratory of Molecular Nephrology, IRCCS Istituto Giannina Gaslini, Genoa, Italy).

Dr. Elena Zocchi
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • characteristics of hormones
  • mechanisms of hormone action
  • structure, subunits and complexes of receptors
  • receptor function, expression and regulation
  • hormone/receptor signaling
  • interactions between receptors and hormones

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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Research

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24 pages, 5731 KiB  
Article
Antiproliferative Role of Natural and Semi-Synthetic Tocopherols on Colorectal Cancer Cells Overexpressing the Estrogen Receptor β
by Irene Falsetti, Gaia Palmini, Roberto Zonefrati, Kristian Vasa, Simone Donati, Cinzia Aurilia, Allegra Baroncelli, Caterina Viglianisi, Francesco Ranaldi, Teresa Iantomasi, Piero Procacci, Stefano Menichetti and Maria Luisa Brandi
Int. J. Mol. Sci. 2025, 26(5), 2305; https://doi.org/10.3390/ijms26052305 - 5 Mar 2025
Viewed by 496
Abstract
Estrogen receptor β (ERβ) is the most highly expressed subtype in the colon epithelium and mediates the protective effect of estrogen against the development of colon cancer. Indeed, the expression of this receptor is inversely related to colorectal cancer progression. Structurally estrogen-like compounds, [...] Read more.
Estrogen receptor β (ERβ) is the most highly expressed subtype in the colon epithelium and mediates the protective effect of estrogen against the development of colon cancer. Indeed, the expression of this receptor is inversely related to colorectal cancer progression. Structurally estrogen-like compounds, including vitamin E components, affect cell growth by binding to ERs. In the present study, cell proliferation was measured by cell counting in a Bürker hemocytometer, and ERβ expression was measured by Real-Time qPCR and immunoenzymatic methods. The results obtained show that natural δ-tocopherol (δ-Toc) and two of its semi-synthetic derivatives, bis-δ-tocopheryl sulfide (δ-Toc)2S and bis-δ-tocopheryl disulfide (δ-Toc)2S2, play an antiproliferative role and upregulate ERβ expression, similar to 17-β-estradiol (17β-E2), in human colon adenocarcinoma HCT8 cells engineered to overexpress ERβ protein (HCT8-β8). These events are not present in HCT8-pSV2neo and in HCT8-β8 pretreated with ICI 182,780, suggesting that they are mediated by the binding of compounds to ERβ, as also boosted by an in silico assay. The antiproliferative effect is independent of the intracellular redox state and (δ-Toc)2S and (δ-Toc)2S2 reduce cell proliferation at concentrations lower than that of δ-Toc and all tested compounds are also able to upregulate ERβ expression. Taken together, the data indicate that, through the involvement of ERβ activity and expression, δ-Toc, (δ-Toc)2S, and (δ-Toc)2S2 may provide potential therapeutic support against colorectal cancer. Full article
(This article belongs to the Special Issue Hormone/Receptor System in Human Diseases)
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Review

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20 pages, 1388 KiB  
Review
Estrogen-Related Receptor α: A Key Transcription Factor in the Regulation of Energy Metabolism at an Organismic Level and a Target of the ABA/LANCL Hormone Receptor System
by Sonia Spinelli, Maurizio Bruschi, Mario Passalacqua, Lucrezia Guida, Mirko Magnone, Laura Sturla and Elena Zocchi
Int. J. Mol. Sci. 2024, 25(9), 4796; https://doi.org/10.3390/ijms25094796 - 27 Apr 2024
Cited by 5 | Viewed by 2727
Abstract
The orphan nuclear receptor ERRα is the most extensively researched member of the estrogen-related receptor family and holds a pivotal role in various functions associated with energy metabolism, especially in tissues characterized by high energy requirements, such as the heart, skeletal muscle, adipose [...] Read more.
The orphan nuclear receptor ERRα is the most extensively researched member of the estrogen-related receptor family and holds a pivotal role in various functions associated with energy metabolism, especially in tissues characterized by high energy requirements, such as the heart, skeletal muscle, adipose tissue, kidney, and brain. Abscisic acid (ABA), traditionally acknowledged as a plant stress hormone, is detected and actively functions in organisms beyond the land plant kingdom, encompassing cyanobacteria, fungi, algae, protozoan parasites, lower Metazoa, and mammals. Its ancient, cross-kingdom role enables ABA and its signaling pathway to regulate cell responses to environmental stimuli in various organisms, such as marine sponges, higher plants, and humans. Recent advancements in understanding the physiological function of ABA and its mammalian receptors in governing energy metabolism and mitochondrial function in myocytes, adipocytes, and neuronal cells suggest potential therapeutic applications for ABA in pre-diabetes, diabetes, and cardio-/neuroprotection. The ABA/LANCL1-2 hormone/receptor system emerges as a novel regulator of ERRα expression levels and transcriptional activity, mediated through the AMPK/SIRT1/PGC-1α axis. There exists a reciprocal feed-forward transcriptional relationship between the LANCL proteins and transcriptional coactivators ERRα/PGC-1α, which may be leveraged using natural or synthetic LANCL agonists to enhance mitochondrial function across various clinical contexts. Full article
(This article belongs to the Special Issue Hormone/Receptor System in Human Diseases)
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