Oral Cancers: Molecular Basis and Treatment Targets
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (29 February 2024) | Viewed by 992
Special Issue Editors
2. Division of Hematology and Oncology, The David Geffen School of Medicine, UCLA, Los Angeles, CA 90095-1668, USA
3. Jonsson Comprehensive Cancer Center, The David Geffen School of Medicine, UCLA, Los Angeles, CA 90095-1668, USA
Interests: molecular carcinogenesis; viral oncology; aging and cell senescence; atherosclerosis and inflammation; periodontitis and the development of atherosclerosis and Alzheimer disease
2. Jonsson Comprehensive Cancer Center, The David Geffen School of Medicine, UCLA, Los Angeles, CA 90095-1668, USA
Interests: molecular mechanisms of oral carcinogenesis; molecular regulation of cancer stem cell genesis and maintenance; molecular mechanisms of cellular senescence and aging; therapeutic application of dental mesenchymal stem cells
Special Issue Information
Dear Colleagues,
Human oral squamous cell carcinoma (HOSCC) is one of the most serious growing worldwide epidemic problems. Tobacco smoking, alcohol consumption, “high-risk” human papillomaviruses (HPVs), and certain bacterial infections are important risk factors for HOSCC. Surgical treatment, often followed by radiotherapy and chemotherapy, is the mode of treatment for HOSCC. Unfortunately, recurrence, metastasis, and severe morbidity are frequent problems after treatment. The 5-year survival for HOSCC is ~50%, which has remained unchanged over the past decade. Moreover, the 5-year survival rate drastically reduces to 35% with the nodal metastasis of cancer cells. Furthermore, the incidence of oropharyngeal cancer associated with HPV infections has been alarmingly elevated among young adults. Thus, identifying and understanding the mechanisms that govern the initiation, progression, and metastasis of HOSCC are imperative, which will result in new directions in HOSCC therapy. We are pleased to invite investigators to submit either original research or review articles to this Special Issue to update the molecular basis of the initiation, progression, metastasis, and treatment of HOSCC.
Prof. Dr. No-Hee Park
Dr. Ki-Hyuk Shin
Guest Editors
Manuscript Submission Information
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Keywords
- carcinogenesis
- cancer stem cells
- cancer metabolism
- radio-chemoresistant
- metastasis
- immunotherapy
